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Literature summary for 1.2.1.3 extracted from

  • diFabio, J.; Ji, Y.; Vasiliou, V.; Thatcher, G.R.; Bennett, B.M.
    Role of mitochondrial aldehyde dehydrogenase in nitrate tolerance (2003), Mol. Pharmacol., 64, 1109-1116.
    View publication on PubMed
Search for more literature for 1.2.1.3

Application

Application Comment Organism
medicine glyceryl trinitrate is used in the treatment of angina pectoris and cardiac failure, but the rapid onset of glyceryl trinitrate tolerance limits its clinical utility.The majority of the vascular ALDH2 is present in the cytoplasm, suggesting that mitochondrial biotransformation of glyceryl trinitrate by ALDH2 plays a minor role in the overall vascular biotransformation Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the majority of the vascular ALDH2 is present in the cytoplasm, suggesting that mitochondrial biotransformation of glyceryl trinitrate by ALDH2 plays a minor role in the overall vascular biotransformation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the majority of the vascular ALDH2 is present in the cytoplasm, suggesting that mitochondrial biotransformation of glyceryl trinitrate by ALDH2 plays a minor role in the overall vascular biotransformation Rattus norvegicus ?
-
 ?
propanal + NAD+ + H2O
-
 Rattus norvegicus propionate + NADH
-
 ?

Synonyms

Synonyms Comment Organism
ALDH2
-
 Rattus norvegicus