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Literature summary for 1.2.1.3 extracted from
- Partial purification and properties of a phenobarbital-induced aldehyde dehydrogenase of rat liver (1975), Biochim. Biophys. Acta, 410, 1-11.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| deoxycorticosterone | activates | Rattus norvegicus |  |
| diethylstilbestrol | activates | Rattus norvegicus | |
| estrone | activates | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Disulfiram | - |
Rattus norvegicus | |
| EDTA | - |
Rattus norvegicus | |
| additional information | substrate inhibition by aromatic aldehydes | Rattus norvegicus | |
| progesterone | - |
Rattus norvegicus | |
| sodium arsenite | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.035 | - |
NAD+ | - |
Rattus norvegicus | |
| 0.55 | - |
propanal | - |
Rattus norvegicus | |
| 4 | - |
acetaldehyde | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Rattus norvegicus | 5737 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial, phenobarbital-induced enzyme | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-carboxybenzaldehyde + NAD+ + H2O | - |
Rattus norvegicus | 4-carboxybenzoate + NADH | - |
? | |
| 4-chlorobenzaldehyde + NAD+ + H2O | - |
Rattus norvegicus | 4-chlorobenzoate + NADH | - |
? | |
| acetaldehyde + NAD+ + H2O | - |
Rattus norvegicus | acetate + NADH + H+ | - |
? | |
| anisaldehyde + NAD+ + H2O | - |
Rattus norvegicus | ? + NADH | - |
? | |
| benzaldehyde + NAD+ + H2O | - |
Rattus norvegicus | benzoate + NADH + H+ | - |
? | |
| butanal + NAD+ + H2O | n-butanal | Rattus norvegicus | butyrate + NADH + H+ | - |
? | |
| formaldehyde + NAD+ + H2O | no activity | Rattus norvegicus | formate + NADH | - |
? | |
| hexanal + NAD+ + H2O | - |
Rattus norvegicus | hexanoate + NADH + H+ | - |
? | |
| m-nitrobenzaldehyde + NAD+ + H2O | - |
Rattus norvegicus | m-nitrobenzoate + NADH | - |
? | |
| p-methoxybenzaldehyde + NAD+ + H2O | - |
Rattus norvegicus | p-methoxybenzoate + NADH + H+ | - |
? | |
| phenylacetaldehyde + NAD+ + H2O | - |
Rattus norvegicus | phenylacetate + NADH + H+ | - |
? | |
| propanal + NAD+ + H2O | - |
Rattus norvegicus | propionate + NADH | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
heat denaturation at 57°C | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9.2 | 9.5 | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Rattus norvegicus | |
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