Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetaldehyde | 0.02 mM, substrate inhibition of isoenzyme I, no inhibition of isoenzyme II and III | Homo sapiens | |
Disulfiram | inhibition of isoenzyme III, isoenzyme I is extremely sensitive, isoenzyme II is totally insensitive | Homo sapiens | |
Mg2+ | isoenzyme III | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0005 | - |
3,4-dihydroxyphenyl acetaldehyde | isoenzyme II | Homo sapiens | |
0.0007 | - |
indole 3-acetaldehyde | isoenzyme I | Homo sapiens | |
0.001 | - |
indole 3-acetaldehyde | isoenzyme III | Homo sapiens | |
0.003 | - |
3,4-dihydroxyphenyl acetaldehyde | isoenzyme III | Homo sapiens | |
0.004 | - |
propanal | isoenzyme III | Homo sapiens | |
0.005 | - |
glycolaldehyde | isoenzyme I | Homo sapiens | |
0.021 | - |
glycolaldehyde | isoenzyme II | Homo sapiens | |
0.048 | - |
acetaldehyde | isoenzyme III | Homo sapiens | |
0.11 | - |
glycolaldehyde | isoenzyme III | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | isoenzyme III | Homo sapiens | 5737 | - |
mitochondrion | isoenzyme I and II | Homo sapiens | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | activation of isoenzyme I and II | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
54000 | - |
4 * 54000, isoenzyme I, II and III, SDS-PAGE | Homo sapiens |
208000 | 210000 | isoenzyme I, non-denaturing PAGE | Homo sapiens |
216000 | - |
isoenzyme II, non-denaturing PAGE | Homo sapiens |
220000 | - |
isoenzyme III, gel filtration | Homo sapiens |
236000 | - |
isoenzyme III, non-denaturing PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.29 | - |
isoenzyme I | Homo sapiens |
0.445 | - |
isoenzyme III | Homo sapiens |
3 | - |
isoenzyme II | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O | - |
Homo sapiens | 3,4-dihydroxyphenylacetate + NADH + H+ | - |
? | |
acetaldehyde + NAD+ + H2O | - |
Homo sapiens | acetate + NADH + H+ | - |
? | |
glycolaldehyde + NAD+ + H2O | - |
Homo sapiens | glycolate + NADH | - |
? | |
indole-3-acetaldehyde + NAD+ + H2O | - |
Homo sapiens | indole-3-acetate + NADH + H+ | - |
? | |
propanal + NAD+ + H2O | - |
Homo sapiens | propionate + NADH | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | 4 * 54000, isoenzyme I, II and III, SDS-PAGE | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
reaction with indole 3-acetaldehyde, isoenzyme III | Homo sapiens |
8.5 | - |
reaction with acetaldehyde and indole 3-acetaldehyde, isoenzyme II | Homo sapiens |
9 | - |
reaction with acetaldehyde, isoenzyme III | Homo sapiens |
9 | - |
reaction with indole 3-acetaldehyde, isoenzyme I | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |