Activating Compound | Comment | Organism | Structure |
---|---|---|---|
diethylstilbestrol | activates | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Disulfiram | - |
Rattus norvegicus | |
p-hydroxymercuribenzoate | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0023 | - |
NAD+ | enzyme from promotion phase of hepatocarcinogenesis | Rattus norvegicus | |
0.0077 | - |
NAD+ | phenobarbital-inducible enzyme | Rattus norvegicus | |
1.3 | - |
propanal | enzyme from promotion phase of hepatocarcinogenesis | Rattus norvegicus | |
1.3 | - |
benzaldehyde | phenobarbital-inducible enzyme | Rattus norvegicus | |
1.4 | - |
propanal | phenobarbital-inducible enzyme | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
enzyme from the promotion phase of hepatocarcinogenesis and phenobabital-inducible enzyme | - |
Purification (Comment) | Organism |
---|---|
enzyme from promotion phase of hepatocarcinogenesis and phenobarbital-inducible enzyme | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
2.07 | - |
enzyme from the promotion phase of hepatocarcinogenesis | Rattus norvegicus |
3.86 | - |
phenobarbital-inducible enzyme | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzaldehyde + NAD+ + H2O | promotion-associated enzyme, no activity with phenobarbital-inducible enzyme | Rattus norvegicus | benzoate + NADH + H+ | - |
? | |
phenylacetaldehyde + NAD+ + H2O | - |
Rattus norvegicus | phenylacetate + NADH + H+ | - |
? | |
propanal + NAD+ + H2O | - |
Rattus norvegicus | propionate + NADH | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
15 min, retains 70% of the original activity | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
10 | - |
- |
Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
9 | 10 | pH 9: about 35% of maximal activity, pH 10: optimum | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | NADP+: promotion-associated enzyme shows 1% of the activity with NAD+, phenobarbital-associated enzyme shows no activity | Rattus norvegicus | |
NAD+ | - |
Rattus norvegicus |