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Literature summary for 1.2.1.24 extracted from

  • Watanabe, S.; Kodaki, T.; Makino, K.
    A novel alpha-ketoglutaric semialdehyde dehydrogenase: evolutionary insight into an alternative pathway of bacterial L-arabinose metabolism (2006), J. Biol. Chem., 281, 28876-28888.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli as His-tag fusion protein Azospirillum brasilense

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.011
-
alpha-Ketoglutaric semialdehyde 1 mM EDTA, 1 mM 2-mercaptoethanol, 66.7 mM potassium phosphate pH 7.2, 1.5 mM NAD+. 25°C Azospirillum brasilense
0.0159
-
alpha-Ketoglutaric semialdehyde 1 mM EDTA, 1 mM 2-mercaptoethanol, 66.7 mM potassium phosphate pH 7.2, 1.5 mM NADP+. 25°C Azospirillum brasilense
0.0163
-
Glutaraldehyde 1 mM EDTA, 1 mM 2-mercaptoethanol, 66.7 mM potassium phosphate pH 7.2, 1.5 mM NAD+. 25°C Azospirillum brasilense
0.0385
-
succinate semialdehyde 1 mM EDTA, 1 mM 2-mercaptoethanol, 66.7 mM potassium phosphate pH 7.2, 1.5 mM NAD+. 25°C Azospirillum brasilense

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
SDS-PAGE Azospirillum brasilense
220000
-
gel-filtration Azospirillum brasilense

Organism

Organism UniProt Comment Textmining
Azospirillum brasilense Q1JUP4
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-affinity chromatography Azospirillum brasilense

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
Azospirillum brasilense
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetaldehyde + NAD+ + H2O
-
Azospirillum brasilense acetate + NADH + H+
-
?
alpha-ketoglutaric semialdehyde + NAD+ + H2O
-
Azospirillum brasilense alpha-ketoglutarate + NADH
-
?
alpha-ketoglutaric semialdehyde + NADP+ + H2O
-
Azospirillum brasilense alpha-ketoglutarate + NADPH
-
?
betaine aldehyde + NAD+ + H2O
-
Azospirillum brasilense 2-trimethylammonioacetate + NADH
-
?
butanaldehyde + NAD+ + H2O
-
Azospirillum brasilense butanoate + NADH
-
?
formaldehyde + NAD+ + H2O
-
Azospirillum brasilense formate + NADH
-
?
glutaraldehyde + NAD+ + H2O
-
Azospirillum brasilense glutarate + NADH
-
?
glyceraldehyde + NAD+ + H2O
-
Azospirillum brasilense glycerate + NADH
-
?
glycoaldehyde + NAD+ + H2O
-
Azospirillum brasilense glycolate + NADH
-
?
heptanaldehyde + NAD+ + H2O
-
Azospirillum brasilense heptanoate + NADH
-
?
hexanaldehyde + NAD+ + H2O
-
Azospirillum brasilense hexanoate + NADH
-
?
isobutyraldehyde + NAD+ + H2O
-
Azospirillum brasilense isobutyrate + NADH + H+
-
?
octanaldehyde + NAD+ + H2O
-
Azospirillum brasilense octanoate + NADH
-
?
pentanaldehyde + NAD+ + H2O
-
Azospirillum brasilense pentanoate + NADH
-
?
propanaldehyde + NAD+ + H2O
-
Azospirillum brasilense propanoate + NADH
-
?
succinate semialdehyde + NAD+ + H2O
-
Azospirillum brasilense succinate + NADH
-
?

Subunits

Subunits Comment Organism
tetramer 4 * 55000, gel-filtration, SDS-PAGE Azospirillum brasilense

Synonyms

Synonyms Comment Organism
alphaKGSA dehydrogenase
-
Azospirillum brasilense
SSALDH
-
Azospirillum brasilense

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
12.3
-
Glutaraldehyde 1 mM EDTA, 1 mM 2-mercaptoethanol, 66.7 mM potassium phosphate pH 7.2, 1.5 mM NAD+. 25°C Azospirillum brasilense
12.3
-
alpha-Ketoglutaric semialdehyde 1 mM EDTA, 1 mM 2-mercaptoethanol, 66.7 mM potassium phosphate pH 7.2, 1.5 mM NADP+. 25°C Azospirillum brasilense
31.7
-
succinate semialdehyde 1 mM EDTA, 1 mM 2-mercaptoethanol, 66.7 mM potassium phosphate pH 7.2, 1.5 mM NAD+. 25°C Azospirillum brasilense
51.2
-
alpha-Ketoglutaric semialdehyde 1 mM EDTA, 1 mM 2-mercaptoethanol, 66.7 mM potassium phosphate pH 7.2, 1.5 mM NAD+. 25°C Azospirillum brasilense