Literature summary for 1.2.1.24 extracted from

Lee, B.R.; Kim, D.W.; Hong, J.W.; Eum, W.S.; Choi, H.S.; Choi, S.H.; Kim, S.Y.; An, J.J.; Ahn, J.Y.; Kwon, O.S.; Kang, T.C.; Won, M.H.; Cho, S.W.; Lee, K.S.; Park, J.; Choi, S.Y.
Brain succinic semialdehyde dehydrogenase. Reactions of sulfhydryl residues connected with catalytic activity (2004), Eur. J. Biochem., 271, 4903-4908.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-dimethylaminoazobenzene-4-iodoacetamide	time-dependent loss of activity, pseudo first-order kinetics. The inhibitor binds to a cysteine residue or near its active site. Inactivation is prevented by preincubation with succinate semialdehyde, but not by preincubation with coenzyme NAD+	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
succinate semialdehyde + NAD+	-	Bos taurus	succinate + NADH + H+	-	?

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Bos taurus

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Release 2023.1 (January 2023)