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Literature summary for 1.2.1.24 extracted from
- Potato tuber succinate semialdehyde dehydrogenase: purification and characterization (1989), Arch. Biochem. Biophys., 275, 469-477.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 2-mercaptoethanol | activates | Solanum tuberosum |  |
| dithiothreitol | activates | Solanum tuberosum | |
| glutathione | activates | Solanum tuberosum | |
| L-Cys | activates | Solanum tuberosum | |
General Stability
| General Stability | Organism |
|---|---|
| freezing in absence of glycerol results in inactivation | Solanum tuberosum |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-hydroxybenzaldehyde | - |
Solanum tuberosum | |
| acetaldehyde | 1 mM, 40% inhibition | Solanum tuberosum | |
| AMP | 1 mM, 17% inhibition | Solanum tuberosum | |
| arsenite | - |
Solanum tuberosum | |
| Cd2+ | - |
Solanum tuberosum | |
| Cu2+ | - |
Solanum tuberosum | |
| Dithionitrobenzoate | - |
Solanum tuberosum | |
| glyoxylate | 1 mM, 33% inhibition | Solanum tuberosum | |
| Hg2+ | - |
Solanum tuberosum | |
| NADH | - |
Solanum tuberosum | |
| NEM | - |
Solanum tuberosum | |
| p-hydroxymercuribenzoate | - |
Solanum tuberosum | |
| Zn2+ | - |
Solanum tuberosum | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0046 | - |
succinate semialdehyde | - |
Solanum tuberosum | |
| 0.031 | - |
NAD+ | - |
Solanum tuberosum | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 35000 | - |
4 * 35000, SDS-PAGE | Solanum tuberosum |
| 145000 | - |
gel filtration | Solanum tuberosum |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Solanum tuberosum | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Solanum tuberosum |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 6.49 | - |
- |
Solanum tuberosum |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, 20 mM sodium diphosphate buffer, pH 7.2, 14 mM 2-mercaptoethanol, 25% v/v glycerol, 2-3 months, retains 80-85% of the activity | Solanum tuberosum |
| 0-2°C, 24 h, 50% loss of activity | Solanum tuberosum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinate semialdehyde + NAD+ + H2O | - |
Solanum tuberosum | succinate + NADH | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 35000, SDS-PAGE | Solanum tuberosum |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9 | - |
- |
Solanum tuberosum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Solanum tuberosum | |
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