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Literature summary for 1.2.1.24 extracted from

  • Tokunaga, M.; Nakano, Y.; Kitaoka, S.
    Separation and properties of the NAD-linked and NADP-linked isozymes of succinic semialdehyde dehydrogenase in Euglena gracilis z (1976), Biochim. Biophys. Acta, 429, 55-62.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
dithiothreitol 1 mM, 17% activation Euglena gracilis

Inhibitors

Inhibitors Comment Organism Structure
5,5'-dithiobis(2-nitrobenzoic acid) 0.01 mM, 66% residual activity Euglena gracilis
Ca2+
-
Euglena gracilis
Mg2+
-
Euglena gracilis
Mn2+
-
Euglena gracilis
N-ethylmaleimide 0.1 mM, complete loss of activity Euglena gracilis
Ni2+
-
Euglena gracilis
succinate semialdehyde substrate inhibition above 2 mM Euglena gracilis
Zn2+ 1 mM, 43% inhibition Euglena gracilis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.071
-
NAD+ pH 8.3, 35°C Euglena gracilis
0.16
-
succinate semialdehyde pH 8.3, 35°C Euglena gracilis

Metals/Ions

Metals/Ions Comment Organism Structure
K+ 5 mM, 84% activation Euglena gracilis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
150000
-
gel filtration Euglena gracilis

Organism

Organism UniProt Comment Textmining
Euglena gracilis
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.25
-
pH 8.3, 35°C Euglena gracilis

Storage Stability

Storage Stability Organism
5°C, unstable unless 30% glycerol is added Euglena gracilis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
malonate semialdehyde + NAD+ + H2O 3.8% of the activity with succinate semialdehyde Euglena gracilis malonate + NADH + 2 H+
-
?
additional information no substrate: glyoxylic acid, formic acid, formaldehyde, acetaldehyde, glyoxal, furfural and acrolein Euglena gracilis ?
-
?
succinate semialdehyde + NAD+ + H2O
-
Euglena gracilis succinate + NADH + 2 H+
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
35 45
-
Euglena gracilis

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
60
-
stable up to Euglena gracilis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.7
-
-
Euglena gracilis

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Euglena gracilis

Expression

Organism Comment Expression
Euglena gracilis induction by growth on glutamate up