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Literature summary for 1.2.1.19 extracted from

  • Tago, K.; Kurioka, S.; Matsuda, M.
    4-Aminobutyraldehyde dehydrogenase activity in rat brain (1982), J. Neurochem., 39, 803-809.
    View publication on PubMed
Search for more literature for 1.2.1.19

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.083
-
 4-Aminobutyraldehyde
-
 Rattus norvegicus
0.48
-
 NAD+
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Rattus norvegicus 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-aminobutanal + NAD+ + H2O Rattus norvegicus synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid in brain 4-aminobutanoate + NADH + H+
-
 ?
4-aminobutanal + NAD+ + H2O Rattus norvegicus Wistar- synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid in brain 4-aminobutanoate + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Wistar-strain
-
Rattus norvegicus Wistar-
-
 Wistar-strain
-

Purification (Commentary)

Purification (Comment) Organism
using ammonium sulfate fractionation and column chromatography on DEAE-cellulose, AMP-Sepharose, Sephadex G-200 and NAD+-Sepharose Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.2
-
-
 Rattus norvegicus

Storage Stability

Storage Stability Organism
-20°C, several months Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-aminopropanal + NAD+ + H2O 17% the rate of 4-aminobutyraldehyde reduction Rattus norvegicus 3-aminopropanoate + NADH + H+
-
 ?
3-aminopropanal + NAD+ + H2O 17% the rate of 4-aminobutyraldehyde reduction Rattus norvegicus Wistar- 3-aminopropanoate + NADH + H+
-
 ?
4-aminobutanal + NAD+ + H2O
-
 Rattus norvegicus 4-aminobutanoate + NADH + H+
-
 ?
4-aminobutanal + NAD+ + H2O synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid in brain Rattus norvegicus 4-aminobutanoate + NADH + H+
-
 ?
4-aminobutanal + NAD+ + H2O
-
 Rattus norvegicus Wistar- 4-aminobutanoate + NADH + H+
-
 ?
4-aminobutanal + NAD+ + H2O synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid in brain Rattus norvegicus Wistar- 4-aminobutanoate + NADH + H+
-
 ?
additional information very low activity with: succinate semialdehyde Rattus norvegicus ?
-
 ?
additional information very low activity with benzaldehyde, propionaldehyde Rattus norvegicus ?
-
 ?
additional information very low activity with: succinate semialdehyde Rattus norvegicus Wistar- ?
-
 ?
additional information very low activity with benzaldehyde, propionaldehyde Rattus norvegicus Wistar- ?
-
 ?
succinate semialdehyde + NAD+ 24% the rate of 4-aminobutyraldehyde reduction Rattus norvegicus succinate + NADH + H+
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
-20
-
 stable over several months Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
 Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6.9 8.5 at pH 6.9: about 30% of activity maximum, at pH 8.5: about 65% of activity maximum Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Rattus norvegicus