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Literature summary for 1.2.1.16 extracted from

  • Jakoby, W.B.; Scott, E.M.
    Aldehyde oxidation III. Succinic semialdehyde dehydrogenase (1959), J. Biol. Chem., 234, 937-940.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
2-mercaptoethanol convenient source of exogenous mercaptan, 5 mM Pseudomonas fluorescens
cysteine
-
Pseudomonas fluorescens
glutathione
-
Pseudomonas fluorescens

Inhibitors

Inhibitors Comment Organism Structure
glyoxylate
-
Pseudomonas fluorescens
malonic semialdehyde
-
Pseudomonas fluorescens
potassium arsenite
-
Pseudomonas fluorescens

Organism

Organism UniProt Comment Textmining
Pseudomonas fluorescens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Pseudomonas fluorescens

Storage Stability

Storage Stability Organism
2°C, pH 7.0, 10% loss of activity per week Pseudomonas fluorescens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinate semialdehyde + NADP+ + H2O
-
Pseudomonas fluorescens succinate + NADPH + H+
-
ir

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
Pseudomonas fluorescens

pH Range

pH Minimum pH Maximum Comment Organism
7 9.3 at pH 7.0 and 9.3: about 30% of activity maximum Pseudomonas fluorescens

pH Stability

pH Stability pH Stability Maximum Comment Organism
6.5 7.1 highest stability Pseudomonas fluorescens

Cofactor

Cofactor Comment Organism Structure
NAD+ NADP+ is about 8.2 times as active as NAD+ Pseudomonas fluorescens
NADP+ NADP+ is 8.2 times as active as NAD+ Pseudomonas fluorescens