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Literature summary for 1.2.1.12 extracted from

  • Guido, R.; Cardoso, C.; De Moraes, M.; Andricopulo, A.; Cass, Q.; Oliva, G.
    Structural insights into the molecular basis responsible for the effects of immobilization on the kinetic parameters of glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi and human (2010), J. Braz. Chem. Soc., 21, 1845-1853.
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.16
-
 D-glyceraldehyde 3-phosphate free enzyme, at pH 8.6 and 25°C Homo sapiens
0.16
-
 D-glyceraldehyde 3-phosphate free enzyme,25°C, pH 8.6 Homo sapiens
0.18
-
 NAD+ free enzyme, at pH 8.6 and 25°C Homo sapiens
0.18
-
 NAD+ free enzyme,25°C, pH 8.6 Homo sapiens
0.26
-
 NAD+ free enzyme, at pH 7.5 and 25°C Trypanosoma cruzi
0.26
-
 NAD+ free enzyme,25°C, pH 8.6 Trypanosoma cruzi
0.42
-
 D-glyceraldehyde 3-phosphate free enzyme, at pH 7.5 and 25°C Trypanosoma cruzi
0.42
-
 D-glyceraldehyde 3-phosphate free enzyme,25°C, pH 8.6 Trypanosoma cruzi
0.5
-
 D-glyceraldehyde 3-phosphate immobilized enzyme reactor, at pH 7.5 and 25°C Trypanosoma cruzi
0.5
-
 D-glyceraldehyde 3-phosphate enzyme covalently immobilized onto an electrophoresis fused-silica capillary, 25°C, pH 8.6 Trypanosoma cruzi
0.67
-
 NAD+ immobilized enzyme reactor, at pH 7.5 and 25°C Trypanosoma cruzi
0.67
-
 NAD+ enzyme covalently immobilized onto an electrophoresis fused-silica capillary, 25°C, pH 8.6 Trypanosoma cruzi
0.75
-
 NAD+ immobilized enzyme reactor, at pH 8.6 and 25°C Homo sapiens
0.75
-
 NAD+ enzyme covalently immobilized onto an electrophoresis fused-silica capillary, 25°C, pH 8.6 Homo sapiens
3.7
-
 D-glyceraldehyde 3-phosphate immobilized enzyme reactor, at pH 8.6 and 25°C Homo sapiens
3.7
-
 D-glyceraldehyde 3-phosphate enzyme covalently immobilized onto an electrophoresis fused-silica capillary, 25°C, pH 8.6 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glyceraldehyde 3-phosphate + phosphate + NAD+ Homo sapiens
-
 3-phospho-D-glyceroyl phosphate + NADH + H+
-
 ?
D-glyceraldehyde 3-phosphate + phosphate + NAD+ Trypanosoma cruzi
-
 3-phospho-D-glyceroyl phosphate + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Trypanosoma cruzi
-
-
-
Trypanosoma cruzi P22513
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glyceraldehyde 3-phosphate + phosphate + NAD+
-
 Homo sapiens 3-phospho-D-glyceroyl phosphate + NADH
-
 ?
D-glyceraldehyde 3-phosphate + phosphate + NAD+
-
 Trypanosoma cruzi 3-phospho-D-glyceroyl phosphate + NADH
-
 ?
D-glyceraldehyde 3-phosphate + phosphate + NAD+
-
 Homo sapiens 3-phospho-D-glyceroyl phosphate + NADH + H+
-
 ?
D-glyceraldehyde 3-phosphate + phosphate + NAD+
-
 Trypanosoma cruzi 3-phospho-D-glyceroyl phosphate + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
GAPDH
-
 Homo sapiens
GAPDH
-
 Trypanosoma cruzi

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens
NAD+
-
 Trypanosoma cruzi