Literature summary for 1.2.1.12 extracted from

Cerella, C.; DAlessio, M.; Cristofanon, S.; De Nicola, M.; Radogna, F.; Dicato, M.; Diederich, M.; Ghibelli, L.
Subapoptogenic oxidative stress strongly increases the activity of the glycolytic key enzyme glyceraldehyde 3-phosphate dehydrogenase (2009), Ann. N. Y. Acad. Sci., 1171, 583-590.

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Activating Compound

Activating Compound	Comment	Organism	Structure
H2O2	subapoptotic doses lead to strong hyperactivation, related to mild oxidative stress. U937 cells hyperactivate glyceraldehyde 3-phosphate dehydrogenase with the same timing observed for glyceraldehyde 3-phosphate dehydrogenase alterations from apoptogenic doses of H2O2	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
U-937 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)