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Literature summary for 1.2.1.12 extracted from

  • Ashmarina, L.I.; Muronetz, V.I.; Nagradova, N.K.
    Evidence for a change in catalytic properties of glyceraldehyde 3-phosphate dehydrogenase monomers upon their association in a tetramer (1982), FEBS Lett., 144, 43-46.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-phospho-D-glyceroyl phosphate + NADH
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Saccharomyces cerevisiae D-glyceraldehyde 3-phosphate + phosphate + NAD+
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r
D-glyceraldehyde 3-phosphate + phosphate + NAD+
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Saccharomyces cerevisiae 3-phospho-D-glyceroyl phosphate + NADH
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r

Subunits

Subunits Comment Organism
More subunit interactions are involved in regulation of activity Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NAD+ activity with D-glyceraldehyde 3-phosphate in presence of 0.0006-0.006 mM NAD+: activity of the monomeric form is negligible or absent, high activity of the tetramer. 0.02-0.06 mM NAD+: markedly higher catalytic activity of the monomer. 2 mM NAD+: specific activities of monomeric and tetrameric forms are similar and equal to 0.06 mM/min. Activity with 3-phospho-D-glyceroyl phosphate: activity of the monomer is considerably higher than that of the tetramer Saccharomyces cerevisiae
NADH cofactor Saccharomyces cerevisiae