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Literature summary for 1.2.1.11 extracted from

  • Oogai, Y.; Yamaguchi, M.; Kawada-Matsuo, M.; Sumitomo, T.; Kawabata, S.; Komatsuzawa, H.
    Lysine and threonine biosynthesis from aspartate contributes to Staphylococcus aureus growth in calf serum (2016), Appl. Environ. Microbiol., 82, 6150-6157 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.11

Protein Variants

Protein Variants Comment Organism
additional information construction of and screening of a library of 2914 transposon-insertional mutants in the Staphylococcus aureus MW2 strain, identification of aspartate semialdehyde dehydrogenase (asd)-inactivated mutant, and inactivated mutants of lysA and thrC defective in lysine and threonine bioynthesis. Identification of Tn551 insertion sites, the Tn551 insertion sites of M3-91 and M17-9 are 276 bp and 347 bp from the initiation of the asd gene, respectively Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-aspartate 4-semialdehyde + phosphate + NADP+ Staphylococcus aureus
-
 L-4-aspartyl phosphate + NADPH + H+
-
 r
L-aspartate 4-semialdehyde + phosphate + NADP+ Staphylococcus aureus MW2
-
 L-4-aspartyl phosphate + NADPH + H+
-
 r

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
 methicillin resistant
-
Staphylococcus aureus MW2
-
 methicillin resistant
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-aspartate 4-semialdehyde + phosphate + NADP+
-
 Staphylococcus aureus L-4-aspartyl phosphate + NADPH + H+
-
 r
L-aspartate 4-semialdehyde + phosphate + NADP+
-
 Staphylococcus aureus MW2 L-4-aspartyl phosphate + NADPH + H+
-
 r

Synonyms

Synonyms Comment Organism
Asd
-
 Staphylococcus aureus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Staphylococcus aureus
NADPH
-
 Staphylococcus aureus

General Information

General Information Comment Organism
malfunction the aspartate semialdehyde dehydrogenase (asd)-inactivated mutant exhibits significantly reduced growth in calf serum compared with the wild-type. The mutant also exhibits significantly reduced growth in medium, mimicking the concentrations of amino acids and glucose in calf serum, but can be recovered by addition of lysine and threonine Staphylococcus aureus
metabolism Asd is an essential enzyme for the biosynthesis of lysine, methionine, and threonine from aspartate Staphylococcus aureus