Cloned (Comment) | Organism |
---|---|
- |
Streptococcus pneumoniae |
- |
Vibrio cholerae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1R)-5-[(2-carboxyphenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate | - |
Streptococcus pneumoniae | |
(1R)-5-[(2-carboxyphenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate | - |
Vibrio cholerae | |
(1R)-5-[(3-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate | - |
Streptococcus pneumoniae | |
(1R)-5-[(3-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate | - |
Vibrio cholerae | |
(1R)-5-[(4-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate | - |
Streptococcus pneumoniae | |
(1R)-5-[(4-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate | - |
Vibrio cholerae | |
(2R,3aR)-5-[(methylsulfonyl)methyl]-2,3,3a,4-tetrahydro-1H-indole-2-carboxylate | - |
Streptococcus pneumoniae | |
(2R,3aR)-5-[(methylsulfonyl)methyl]-2,3,3a,4-tetrahydro-1H-indole-2-carboxylate | - |
Vibrio cholerae | |
(2R,5R)-2,3,4,5-tetrahydropyridine-2,5-dicarboxylate | - |
Streptococcus pneumoniae | |
(2R,5R)-2,3,4,5-tetrahydropyridine-2,5-dicarboxylate | - |
Vibrio cholerae | |
(2R,5R)-5-nitro-2,3,4,5-tetrahydropyridine-2-carboxylate | - |
Streptococcus pneumoniae | |
(2R,5R)-5-nitro-2,3,4,5-tetrahydropyridine-2-carboxylate | - |
Vibrio cholerae | |
(2R,7aR)-2,3,7,7a-tetrahydro-1H-indole-2,6-dicarboxylate | - |
Streptococcus pneumoniae | |
(2R,7aR)-2,3,7,7a-tetrahydro-1H-indole-2,6-dicarboxylate | - |
Vibrio cholerae | |
(2R,7aR)-6-hydroxy-2,3,7,7a-tetrahydro-1H-indole-2-carboxylate | - |
Streptococcus pneumoniae | |
(2R,7aR)-6-hydroxy-2,3,7,7a-tetrahydro-1H-indole-2-carboxylate | - |
Vibrio cholerae | |
(2R,7aR)-6-nitro-2,3,7,7a-tetrahydro-1H-indole-2-carboxylate | - |
Streptococcus pneumoniae | |
(2R,7aR)-6-nitro-2,3,7,7a-tetrahydro-1H-indole-2-carboxylate | - |
Vibrio cholerae | |
(2R,8aR)-2,7-dinitro-1,2,8,8a-tetrahydronaphthalene | - |
Streptococcus pneumoniae | |
(2R,8aR)-2,7-dinitro-1,2,8,8a-tetrahydronaphthalene | - |
Vibrio cholerae | |
(3aR)-2-oxo-2,3,3a,4-tetrahydro-1H-benzimidazole-5-carboxylic acid | - |
Streptococcus pneumoniae | |
(3aR)-2-oxo-2,3,3a,4-tetrahydro-1H-benzimidazole-5-carboxylic acid | - |
Vibrio cholerae | |
(3aR)-5-nitro-1,3,3a,4-tetrahydro-2H-benzimidazol-2-one | - |
Streptococcus pneumoniae | |
(3aR)-5-nitro-1,3,3a,4-tetrahydro-2H-benzimidazol-2-one | - |
Vibrio cholerae | |
(3aR)-5-nitro-3a,4-dihydro-1H-indene-1,3(2H)-dione | - |
Streptococcus pneumoniae | |
(3aR)-5-nitro-3a,4-dihydro-1H-indene-1,3(2H)-dione | - |
Vibrio cholerae | |
(3aR)-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione | - |
Streptococcus pneumoniae | |
(3aR)-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione | - |
Vibrio cholerae | |
(3aR)-6-chloro-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione | - |
Streptococcus pneumoniae | |
(3aR)-6-chloro-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione | - |
Vibrio cholerae | |
(7aR)-2-oxo-2,3,7,7a-tetrahydro-1H-indole-6-carboxylate | - |
Streptococcus pneumoniae | |
(7aR)-2-oxo-2,3,7,7a-tetrahydro-1H-indole-6-carboxylate | - |
Vibrio cholerae | |
(7aR)-3-(carboxylatomethyl)-6-nitro-7,7a-dihydro-1H-indole-2-carboxylate | - |
Streptococcus pneumoniae | |
(7aR)-3-(carboxylatomethyl)-6-nitro-7,7a-dihydro-1H-indole-2-carboxylate | - |
Vibrio cholerae | |
2-Aminoadipate | - |
Streptococcus pneumoniae | |
2-Aminoadipate | - |
Vibrio cholerae | |
4-nitro-N,N-diethylbenzimidazolinone | - |
Streptococcus pneumoniae | |
4-nitro-N,N-diethylbenzimidazolinone | - |
Vibrio cholerae | |
4-nitro-N,N-dimethylbenzimidazolinone | - |
Streptococcus pneumoniae | |
4-nitro-N,N-dimethylbenzimidazolinone | - |
Vibrio cholerae | |
4-nitro-N-ethylphthalimide | - |
Streptococcus pneumoniae | |
4-nitro-N-ethylphthalimide | - |
Vibrio cholerae | |
4-nitro-N-methylphthalimide | - |
Streptococcus pneumoniae | |
4-nitro-N-methylphthalimide | - |
Vibrio cholerae | |
5-(carboxylatocarbonyl)-1H-pyrrole-2-carboxylate | - |
Streptococcus pneumoniae | |
5-(carboxylatocarbonyl)-1H-pyrrole-2-carboxylate | - |
Vibrio cholerae | |
5-[[(4-nitrophenyl)amino]carbonyl]-1,3-benzenedimethylcarboxylate | - |
Streptococcus pneumoniae | |
5-[[(4-nitrophenyl)amino]carbonyl]-1,3-benzenedimethylcarboxylate | - |
Vibrio cholerae | |
dimethyl pyridine-2,5-dicarboxylate | - |
Streptococcus pneumoniae | |
dimethyl pyridine-2,5-dicarboxylate | - |
Vibrio cholerae | |
methyl 5-nitropyridine-2-carboxylate | - |
Streptococcus pneumoniae | |
methyl 5-nitropyridine-2-carboxylate | - |
Vibrio cholerae | |
thieno[2,3-b]thiophene-2,5-dicarboxylate | - |
Streptococcus pneumoniae | |
thieno[2,3-b]thiophene-2,5-dicarboxylate | - |
Vibrio cholerae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-4-aspartyl phosphate + NADPH + H+ | Streptococcus pneumoniae | - |
L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
r | |
L-4-aspartyl phosphate + NADPH + H+ | Vibrio cholerae | - |
L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pneumoniae | - |
- |
- |
Vibrio cholerae | Q9KQG2 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Streptococcus pneumoniae |
- |
Vibrio cholerae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-4-aspartyl phosphate + NADPH + H+ | - |
Streptococcus pneumoniae | L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
r | |
L-4-aspartyl phosphate + NADPH + H+ | - |
Vibrio cholerae | L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
ASADH | - |
Streptococcus pneumoniae |
ASADH | - |
Vibrio cholerae |
aspartate semialdehyde dehydrogenase | - |
Streptococcus pneumoniae |
aspartate semialdehyde dehydrogenase | - |
Vibrio cholerae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Streptococcus pneumoniae | |
NADPH | - |
Vibrio cholerae |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.086 | - |
4-nitro-N,N-dimethylbenzimidazolinone | in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Streptococcus pneumoniae | |
0.086 | - |
4-nitro-N,N-dimethylbenzimidazolinone | in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Vibrio cholerae | |
0.11 | - |
(1R)-5-[(4-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate | in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Streptococcus pneumoniae | |
0.15 | - |
(3aR)-6-chloro-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione | in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Streptococcus pneumoniae | |
0.18 | - |
(3aR)-6-chloro-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione | in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Vibrio cholerae | |
0.18 | - |
(1R)-5-[(4-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate | in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Vibrio cholerae | |
0.4 | - |
(3aR)-5-nitro-1,3,3a,4-tetrahydro-2H-benzimidazol-2-one | in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Streptococcus pneumoniae | |
0.69 | - |
(2R,5R)-2,3,4,5-tetrahydropyridine-2,5-dicarboxylate | in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Streptococcus pneumoniae | |
0.89 | - |
4-nitro-N-methylphthalimide | in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Streptococcus pneumoniae | |
1.1 | - |
4-nitro-N-methylphthalimide | in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Vibrio cholerae | |
1.1 | - |
(3aR)-5-nitro-1,3,3a,4-tetrahydro-2H-benzimidazol-2-one | in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Vibrio cholerae | |
1.2 | - |
(2R,5R)-5-nitro-2,3,4,5-tetrahydropyridine-2-carboxylate | in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Streptococcus pneumoniae | |
1.2 | - |
(2R,5R)-2,3,4,5-tetrahydropyridine-2,5-dicarboxylate | in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Vibrio cholerae | |
2.1 | - |
(2R,5R)-5-nitro-2,3,4,5-tetrahydropyridine-2-carboxylate | in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Vibrio cholerae | |
2.6 | - |
(3aR)-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione | in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Vibrio cholerae | |
3.3 | - |
(3aR)-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione | in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Streptococcus pneumoniae | |
4 | - |
4-nitro-N-ethylphthalimide | Ki above 4 mM in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Streptococcus pneumoniae | |
4 | - |
4-nitro-N-ethylphthalimide | Ki above 4 mM in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Vibrio cholerae | |
4 | - |
4-nitro-N,N-diethylbenzimidazolinone | Ki above 4 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Streptococcus pneumoniae | |
4 | - |
4-nitro-N,N-diethylbenzimidazolinone | Ki above 4 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Vibrio cholerae | |
20 | - |
methyl 5-nitropyridine-2-carboxylate | Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Streptococcus pneumoniae | |
20 | - |
methyl 5-nitropyridine-2-carboxylate | Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Vibrio cholerae | |
20 | - |
dimethyl pyridine-2,5-dicarboxylate | Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Streptococcus pneumoniae | |
20 | - |
dimethyl pyridine-2,5-dicarboxylate | Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Vibrio cholerae | |
20 | - |
5-[[(4-nitrophenyl)amino]carbonyl]-1,3-benzenedimethylcarboxylate | Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Streptococcus pneumoniae | |
20 | - |
5-[[(4-nitrophenyl)amino]carbonyl]-1,3-benzenedimethylcarboxylate | Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C | Vibrio cholerae |