Application | Comment | Organism |
---|---|---|
medicine | target for antibiotic development | Helicobacter pylori |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Helicobacter pylori |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
petrosamine B | 50% inhibition at 0.306 mM. Petrosamine B is a pyridoacridine alkaloid isolated from the sponge Oceanapia sp.; isolated from the methanol extract of the saustralian sponge Oceanapia sp. | Helicobacter pylori |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-aspartate 4-semialdehyde + phosphate + NADP+ | Helicobacter pylori | - |
L-4-aspartyl phosphate + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Helicobacter pylori | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni-affinity chromatography | Helicobacter pylori |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
Helicobacter pylori | L-4-aspartyl phosphate + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Asd | - |
Helicobacter pylori |
aspartate semialdehyde dehydrogenase | - |
Helicobacter pylori |
aspartate-semialdehyde dehydrogenase | - |
Helicobacter pylori |
aspartyl semialdehyde dehydrogenase | - |
Helicobacter pylori |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
23 | - |
activity assay | Helicobacter pylori |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
activity assay | Helicobacter pylori |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Helicobacter pylori | |
NADPH | - |
Helicobacter pylori |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.306 | - |
- |
Helicobacter pylori | petrosamine B |