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Literature summary for 1.2.1.105 extracted from

  • Lu, X.; Yang, P.; Zhao, X.; Jiang, M.; Hu, S.; Ouyang, Y.; Zeng, L.; Wu, J.
    OGDH mediates the inhibition of SIRT5 on cell proliferation and migration of gastric cancer (2019), Exp. Cell Res., 382, 111483 .
    View publication on PubMed
Search for more literature for 1.2.1.105

Cloned(Commentary)

Cloned (Comment) Organism
expressed in 293 T cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information desuccinylation of the enzyme by SIRT5 inhibits the activity of the enzyme complex Homo sapiens
succinyl phosphonate
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-oxoglutarate + CoA + NAD+ Homo sapiens
-
 succinyl-CoA + CO2 + NADH
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AGS cell
-
 Homo sapiens
-
gastric cancer cell
-
 Homo sapiens
-
gastric epithelial cell
-
 Homo sapiens
-
SGC-7901 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutarate + CoA + NAD+
-
 Homo sapiens succinyl-CoA + CO2 + NADH
-
 ?

Synonyms

Synonyms Comment Organism
2-oxoglutarate dehydrogenase
-
 Homo sapiens
OGDH
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme mediates the inhibition of SIRT5 on cell proliferation and migration of gastric cancer Homo sapiens