Literature summary for 1.2.1.105 extracted from

Tsepkova, P.M.; Artiukhov, A.V.; Boyko, A.I.; Aleshin, V.A.; Mkrtchyan, G.V.; Zvyagintseva, M.A.; Ryabov, S.I.; Ksenofontov, A.L.; Baratova, L.A.; Graf, A.V.; Bunik, V.I.
Thiamine induces long-term changes in amino acid profiles and activities of 2-oxoglutarate and 2-oxoadipate dehydrogenases in rat brain (2017), Biochemistry, 82, 723-736 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
thiamine	in the brain stem and cerebellum, the enzyme activity is significantly increased by thiamine (400 mg/kg)	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2-oxoglutarate + CoA + NAD+	Rattus norvegicus	-	succinyl-CoA + CO2 + NADH	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
brain stem	-	Rattus norvegicus	-
cerebellum	-	Rattus norvegicus	-
cerebral cortex	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-oxoglutarate + CoA + NAD+	-	Rattus norvegicus	succinyl-CoA + CO2 + NADH	-	?

Synonyms

Synonyms	Comment	Organism
2-oxoglutarate dehydrogenase complex	-	Rattus norvegicus
OGDHC	-	Rattus norvegicus

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Release 2023.1 (January 2023)