Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,2,3,4-tetrahydroisoquinoline | IC50: 18.2 | Rattus norvegicus | |
1-methyl-4-phenylpyridinium | IC50: 18.9 mM | Rattus norvegicus | |
Isoquinoline | IC50: 6.5 mM | Rattus norvegicus | |
N-methyl-1,2,3,4-tetrahydroisoquinoline | IC50: 2 mM | Rattus norvegicus | |
N-methylisoquinolinium | - |
Rattus norvegicus | |
N-n-propylisoquinolinium | IC50: 3 mM | Rattus norvegicus | |
salsolinol | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-oxoglutarate + lipoamide | Rattus norvegicus | catalyzes a rate limiting step of the TCA cycle | S-succinyldihydrolipoamide + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | the enzyme complex catalyzes the reaction : 2-oxoglutarate + CoA + NAD+--> succinyl-CoA + CO2 + NADH, the following partial reactions are catalyzed: 1. HOOC(CH2)2COCOOH + (thiamine diphosphate)-E1--> (HOOC(CH2)2 CHOH-thiamine-diphosphate)-E1 + CO2, 2. (HOOC(CH2)2CH OH-thiamine-diphosphate)-E1 + (LipS2)-E2--> (HOOC(CH)2 CO-(SLipSH))-E2 + (thiamine-diphosphate)-E1, 3. (HOOC(CH2)2CO-(SLipSH))-E2 + HSCoA--> (Lip(SH)2)-E2 + HOOC(CH2)2CO-SCoA, 4. (Lip(SH)2)-E2 + E3-FAD--> (LipS2)-E2 + reduced E3-FAD, 5. reduced E3-FAD + NAD+--> E3-FAD + NADH | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | forebrain | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-oxoglutarate + lipoamide | - |
Rattus norvegicus | S-succinyldihydrolipoamide + CO2 | - |
? | |
2-oxoglutarate + lipoamide | catalyzes a rate limiting step of the TCA cycle | Rattus norvegicus | S-succinyldihydrolipoamide + CO2 | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
2 | - |
IC50: 2 mM | Rattus norvegicus | N-methyl-1,2,3,4-tetrahydroisoquinoline | |
3 | - |
IC50: 3 mM | Rattus norvegicus | N-n-propylisoquinolinium | |
6.5 | - |
IC50: 6.5 mM | Rattus norvegicus | Isoquinoline | |
18.2 | - |
IC50: 18.2 mM | Rattus norvegicus | 1,2,3,4-tetrahydroisoquinoline | |
18.9 | - |
IC50: 18.9 mM | Rattus norvegicus | 1-methyl-4-phenylpyridinium |