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Literature summary for 1.2.1.104 extracted from

  • Thompson, P.; Reid, E.E.; Lyttle, C.R.; Dennis, D.T.
    Pyruvate dehydrogenase complex from higher plant mitochondria and proplastids kinetics (1977), Plant Physiol., 59, 849-853 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.104

Inhibitors

Inhibitors Comment Organism Structure
acetyl-CoA uncompetitive with respect to pyruvate, noncompetitive with respect to CoA and NAD+ Pisum sativum
acetyl-CoA uncompetitive with respect to pyruvate, noncompetitive with respect to CoA and NAD+ Ricinus communis
NADH competitive with respect to NAD+, noncompetitive with respect to CoA and pyruvate Pisum sativum
NADH competitive with respect to NAD+, noncompetitive with respect to CoA and pyruvate Ricinus communis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.004
-
 CoA pH not specified in the publication, temperature not specified in the publication Pisum sativum
0.0046
-
 CoA pH not specified in the publication, temperature not specified in the publication Ricinus communis
0.053
-
 pyruvate pH not specified in the publication, temperature not specified in the publication Ricinus communis
0.072
-
 pyruvate pH not specified in the publication, temperature not specified in the publication Pisum sativum
0.1
-
 NAD+ pH not specified in the publication, temperature not specified in the publication Ricinus communis
0.238
-
 NAD+ pH not specified in the publication, temperature not specified in the publication Pisum sativum

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Pisum sativum 5739
-
mitochondrion
-
 Ricinus communis 5739
-

Organism

Organism UniProt Comment Textmining
Pisum sativum
-
-
-
Ricinus communis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information substrate interaction kinetics for all substrates are consistent with a multisite ping-pong mechanism Pisum sativum ?
-
-
additional information substrate interaction kinetics for all substrates are consistent with a multisite ping-pong mechanism Ricinus communis ?
-
-
pyruvate + CoA + NAD+
-
 Pisum sativum acetyl-CoA + CO2 + NADH
-
 ?
pyruvate + CoA + NAD+
-
 Ricinus communis acetyl-CoA + CO2 + NADH
-
 ?