KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0006 | - |
pyruvate | cooperativity is observed, Hill coefficient is 1.6, pH 7.6, 37°C | Salmonella enterica subsp. enterica serovar Typhimurium |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyruvate + CoA + NAD+ | Salmonella enterica subsp. enterica serovar Typhimurium | - |
acetyl-CoA + CO2 + NADH | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Salmonella enterica subsp. enterica serovar Typhimurium |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
41 | - |
pH 7.6, 37°C | Salmonella enterica subsp. enterica serovar Typhimurium |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyruvate + CoA + NAD+ | - |
Salmonella enterica subsp. enterica serovar Typhimurium | acetyl-CoA + CO2 + NADH | - |
? |
Subunits | Comment | Organism |
---|---|---|
multimer | x * 100000, pyruvate dehydrogenase, x * 87000, dihydrolipoamide transacetylase (acetyl-CoA:dihydrolipoamide S-acetyltransferase, EC 2.3.1.12), and x * 56000, dihydrolipoamide dehydrogenase (NADH:lipoamide oxidoreductase, EC 1.6.4.3) components, respectively, SDS-PAGE | Salmonella enterica subsp. enterica serovar Typhimurium |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thiamine diphosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
General Information | Comment | Organism |
---|---|---|
physiological function | complete cross-reactivity is found with antibodies directed against the pyruvate dehydrogenase complex from Escherichia coli and electron micrographs of both enzyme complexes reveal identical structures | Salmonella enterica subsp. enterica serovar Typhimurium |