Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyruvate + CoA + NAD+ | Rattus norvegicus | - |
acetyl-CoA + CO2 + NADH | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | PDH activity is inhibited by the phosphorylation of its E1alpha1 subunit | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyruvate + CoA + NAD+ | - |
Rattus norvegicus | acetyl-CoA + CO2 + NADH | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDH | - |
Rattus norvegicus |
PDHE1alpha1 | subunit | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Rattus norvegicus | |
thiamine diphosphate | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | PDHE1alpha1 protein and phosphorylation level decrease significantly ipsilateral to controlled cortical impact and contralateral to controlled cortical impact at 4 h, 24 h, 3- and 7-day post-controlled cortical impact, respectively | down |
Rattus norvegicus | there is a moderate increase of PDHE1alpha1 mRNA in ipsilateral CCI and contralateral controlled cortical impact (1.2-1.6fold) at 4 h and 24 h post-controlled cortical impact. PDHE1alpha1 mRNA increases moderately (1.4fold) in the craniotomy group at 4 h, 24 h and 7-day post-surgery | up |
General Information | Comment | Organism |
---|---|---|
physiological function | pyruvate dehydrogenase is the rate-limiting enzyme coupling cytosolic glycolysis to mitochondrial citric acid cycle, and plays a critical role in maintaining homeostasis of brain glucose metabolism | Rattus norvegicus |