Protein Variants | Comment | Organism |
---|---|---|
D289A | the mutant does not have any detectable activity in PDC assay while its activity in thedecarboxylation reaction measured by 2,6-dichlorophenolindophenol assay does not significantly change | Homo sapiens |
D289N | the mutant does not demonstrate any change in the 2,6-dichlorophenolindophenol assay but its activity is reduced to 67% in PDC assay | Homo sapiens |
E229A | the mutant does not show any significant changes compared with the wild type subunit E1 activity | Homo sapiens |
E229Q | the mutant does not show any significant changes compared with the wild type subunit E1 activity | Homo sapiens |
E232A | the mutant does not show any significant changes compared with the wild type subunit E1 activity | Homo sapiens |
E232Q | the mutant does not show any significant changes compared with the wild type subunit E1 activity | Homo sapiens |
E234A | the mutant does not show any significant changes compared with the wild type subunit E1 activity | Homo sapiens |
E234Q | the mutant does not show any significant changes compared with the wild type subunit E1 activity | Homo sapiens |
I329A | the mutant shows reductions in activities in both the 2,6-dichlorophenolindophenol and PDC assays | Homo sapiens |
I329del | the mutant shows reductions in activities in both the 2,6-dichlorophenolindophenol and PDC assays | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the pyruvate dehydrogenase complex consists of multiple copies of several components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2), dihydrolipoamide dehydrogenase (E3), E3-binding protein (BP), and specific kinases and phosphatases | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the pyruvate dehydrogenase complex consists of multiple copies of several components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2), dihydrolipoamide dehydrogenase (E3), E3-binding protein (BP), and specific kinases and phosphatases | Homo sapiens | ? | - |
? | |
pyruvate + CoA + NAD+ | - |
Homo sapiens | acetyl-CoA + CO2 + NADH | - |
? | |
pyruvate + CoA + oxidized 2,6-dichlorophenolindophenol | - |
Homo sapiens | acetyl-CoA + CO2 + reduced 2,6-dichlorophenolindophenol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDC | - |
Homo sapiens |
PDH | - |
Homo sapiens |
pyruvate dehydrogenase complex | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens | |
thiamine diphosphate | - |
Homo sapiens |