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Literature summary for 1.2.1.104 extracted from

  • Jiang, X.R.; Dryhurst, G.
    Inhibition of the alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase complexes by a putative aberrant metabolite of serotonin, tryptamine-4,5-dione (2002), Chem. Res. Toxicol., 15, 1242-1247.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ADP stimulates Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
tryptamine-4,5-dione inhibition is blocked by reduced glutathione or cysteine at large molar excess, ascorbate protects partially Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-
mitochondrion
-
Rattus norvegicus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus pyruvate-supported mitochondrial respiration state 3 ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
enzyme is in complex with alpha-ketoglutarate dehydrogenase
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information pyruvate-supported mitochondrial respiration state 3 Rattus norvegicus ?
-
?
pyruvate + CoA + NAD+
-
Rattus norvegicus acetyl-CoA + CO2 + NADH
-
ir

Synonyms

Synonyms Comment Organism
PDHC enzyme in complex with alpha-ketoglutarate dehydrogenase Rattus norvegicus
pyruvate dehydrogenase complex enzyme in complex with alpha-ketoglutarate dehydrogenase Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Rattus norvegicus
thiamine diphosphate
-
Rattus norvegicus