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Literature summary for 1.19.1.1 extracted from

  • Wan, J.T.; Jarrett, J.T.
    Electron acceptor specificity of ferredoxin (flavodoxin):NADP+ oxidoreductase from Escherichia coli (2002), Arch. Biochem. Biophys., 406, 116-126.
    View publication on PubMed
Search for more literature for 1.19.1.1

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.004
-
 reduced flavodoxin II pH 8.0, 25°C Escherichia coli
0.0076
-
 reduced flavodoxin I pH 8.0, 25°C Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
FMNH2 + NADP+ Escherichia coli
-
 FMN + NADPH + H+
-
 ?
additional information Escherichia coli the enzyme reduces flavodoxin I, flavodoxin II and ferredoxin, ferredoxin being the kinetically and thermodynamically preferred partner, i.e. reaction of EC 1.18.2.1. Flavodoxin I and flavodoxin II behave similarly with respect to FNR, with affinities about 4- to 7fold weaker and reduction rates that are 10- to 100fold slower than those for ferredoxin. Flavodoxin I and flavodoxin II can obtain electrons from reduced Fd at rates that are comparable to those obtained with reduced FNR ?
-
 ?
reduced flavodoxin I + NADP+ Escherichia coli
-
 oxidized flavodoxin I + NADPH + H+
-
 ?
reduced flavodoxin II + NADP+ Escherichia coli
-
 oxidized flavodoxin II + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P28861 enzyme catalyzes reactions of both EC 1.18.1.2 and EC 1.19.1.1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
FMNH2 + NADP+
-
 Escherichia coli FMN + NADPH + H+
-
 ?
additional information the enzyme reduces flavodoxin I, flavodoxin II and ferredoxin, ferredoxin being the kinetically and thermodynamically preferred partner, i.e. reaction of EC 1.18.2.1. Flavodoxin I and flavodoxin II behave similarly with respect to FNR, with affinities about 4- to 7fold weaker and reduction rates that are 10- to 100fold slower than those for ferredoxin. Flavodoxin I and flavodoxin II can obtain electrons from reduced Fd at rates that are comparable to those obtained with reduced FNR Escherichia coli ?
-
 ?
reduced flavodoxin I + NADP+
-
 Escherichia coli oxidized flavodoxin I + NADPH + H+
-
 ?
reduced flavodoxin II + NADP+
-
 Escherichia coli oxidized flavodoxin II + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
ferredoxin (flavodoxin):NADP+ oxidoreductase
-
 Escherichia coli

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0039
-
 reduced flavodoxin II pH 8.0, 25°C Escherichia coli
0.0042
-
 reduced flavodoxin I pH 8.0, 25°C Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Escherichia coli

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
550
-
 reduced flavodoxin I pH 8.0, 25°C Escherichia coli
980
-
 reduced flavodoxin II pH 8.0, 25°C Escherichia coli
19000
-
 FMNH2 pH 8.0, 25°C Escherichia coli