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Literature summary for 1.18.1.2 extracted from

  • Krapp, A.R.; Rodriguez, R.E.; Poli, H.O.; Paladini, D.H.; Palatnik, J.F.; Carrillo, N.
    The flavoenzyme ferredoxin (flavodoxin)-NADP(H) reductase modulates NADP(H) homeostasis during the soxRS response of Escherichia coli (2002), J. Bacteriol., 184, 1474-1480.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
Y308S mutant uses NAD(H) instead of NADP(H), expression of the mutant has no effect on soxRS induction and fails to protect FPR deficient cells from methyl viologen toxicity Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P28861 enzyme catalyzes reactions of both EC 1.18.1.2 and EC 1.19.1.1
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General Information

General Information Comment Organism
physiological function Escherichia coli cells deficient in the soxRS-induced ferredoxin (flavodoxin)-NADP(H) reductase FPR, display abnormal sensitivity to methyl viologen. Neither bacteriostatic effects nor inactivation of oxidant-sensitive hydrolyases can be detected in mutant cells exposed to methyl viologen. FPR inactivation does not affect the methyl viologen-driven soxRS response, FPR overexpression leads to enhanced stimulation of the regulon, with concomitant oxidation of the NADPH pool. Accumulation of a site-directed FPR mutant that uses NAD(H) instead of NADP(H) has no effect on soxRS induction and fails to protect FPR deficient cells from methyl viologen toxicity Escherichia coli