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Literature summary for 1.17.7.4 extracted from

  • Hsieh, W.Y.; Hsieh, M.H.
    The amino-terminal conserved domain of 4-hydroxy-3-methylbut-2-enyl diphosphate reductase is critical for its function in oxygen-evolving photosynthetic organisms (2015), Plant Signal. Behav., 10, e988072.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.17.7.4

Cloned(Commentary)

Cloned (Comment) Organism
gene ispH, the IspH domain of the Arabidopsis thaliana enzyme HDR corresponding to the full-length IspH of Escherichia coli fails to complement the Escherichia coli ispH mutant Arabidopsis thaliana

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+
-
 Arabidopsis thaliana
Iron-sulfur cluster
-
 Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ Arabidopsis thaliana
-
 isopentenyl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ Arabidopsis thaliana
-
 dimethylallyl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q94B35 gene ispH
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
-
 Arabidopsis thaliana isopentenyl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
-
 Arabidopsis thaliana dimethylallyl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?

Synonyms

Synonyms Comment Organism
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
-
 Arabidopsis thaliana
HDR
-
 Arabidopsis thaliana
isoprenoid synthesis H
-
 Arabidopsis thaliana
ispH
-
 Arabidopsis thaliana
lysis-tolerant B
-
 Arabidopsis thaliana
LytB
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
Ferredoxin
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
evolution compared with the bacterial IspH, cyanobacterial and plant HDRs all contain an extra N-terminal conserved domain (NCD) that is essential for their function. Tyr72 in the NCD and several plant-specific residues around the central active site are critical for Arabidopsis HDR function Arabidopsis thaliana
metabolism the enzyme catalyzes the last step of the methylerythritol phosphate pathway to synthesize isopentenyl diphosphate and dimethylallyl diphosphate Arabidopsis thaliana
additional information the enzyme contains an extra N-terminal conserved domain (NCD) that is essential for its function. Tyr72 in the NCD and several plant-specific residues around the central active site are critical for Arabidopsis HDR function, homology modeling and substrate docking of the IspH domain of the Arabidopsis enzyme HDR, sequence comparisons, overview Arabidopsis thaliana