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Literature summary for 1.17.7.3 extracted from

  • Wang, W.; Oldfield, E.
    Bioorganometallic chemistry with IspG and IspH Structure, function, and inhibition of the [Fe4S4] proteins involved in isoprenoid biosynthesis (2014), Angew. Chem. Int. Ed. Engl., 53, 4294-4310 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.17.7.3

Inhibitors

Inhibitors Comment Organism Structure
aminosulfonylcarbamate weak inhibitor Thermus thermophilus
N-acyl-N'-oxysulfamate weak inhibitor Thermus thermophilus
prop-2-yn-1-yl trihydrogen diphosphate
-
 Thermus thermophilus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin Thermus thermophilus
-
 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin
-
 ?

Organism

Organism UniProt Comment Textmining
Thermus thermophilus Q72H18
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin
-
 Thermus thermophilus 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin
-
 ?
[(2R,3R)-3-(hydroxymethyl)-3-methyloxiran-2-yl]methyl trihydrogen diphosphate + O2
-
 Thermus thermophilus [(2R,3R)-3-(hydroxymethyl)-3-methyloxiran-2-yl]methyl trihydrogen diphosphate + H2O
-
 ?

Synonyms

Synonyms Comment Organism
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
-
 Thermus thermophilus
GcpE
-
 Thermus thermophilus
IspG
-
 Thermus thermophilus

Cofactor

Cofactor Comment Organism Structure
[4Fe-4S]-center
-
 Thermus thermophilus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0067
-
 pH and temperature not specified in the publication Thermus thermophilus prop-2-yn-1-yl trihydrogen diphosphate