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Literature summary for 1.17.4.5 extracted from

  • Van Horn, W.D.
    Structural and functional insights into human vitamin K epoxide reductase and vitamin K epoxide reductase-like1 (2013), Crit. Rev. Biochem. Mol. Biol., 48, 357-372.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
the VKOR-like gene that encodes hVKORL1 that is found on chromosome 7, sequence comparisons Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information non-VKOR, warfarin-sensitive enzyme, while hVKORL is mainly insensitive to inhibition by warfarin, but about 30% of hVKORL1 is inhibited by 0.005 mM warfarin, VKORL1 is warfarin sensitive, but not affect warfarin dosage requirements Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum membrane integral membrane protein Homo sapiens 5789
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O Homo sapiens
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2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
?
additional information Homo sapiens the enzyme, driven by the reducing agent DTT, reduces both vitamin K 2,3-epoxide and vitamin K to the activated hydroquinone form ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N0U8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O
-
Homo sapiens 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
?
additional information the enzyme, driven by the reducing agent DTT, reduces both vitamin K 2,3-epoxide and vitamin K to the activated hydroquinone form Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
non-VKOR
-
Homo sapiens
vitamin K epoxide reductase-like1
-
Homo sapiens
VKOR-like1
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Homo sapiens
VKORL1
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Homo sapiens

General Information

General Information Comment Organism
evolution VKORL1, EC 1.1.4.2, is more highly conserved among vertebrates than its evolutionary relative VKOR, EC 1.1.4.1. The human paralogous proteins are 42-60% identical Homo sapiens
metabolism vitamin K cycle, overview Homo sapiens
physiological function vitamin K dependent oxidative protection is independent of VKOR inhibition by warfarin and GGCX inhibition by 2-chloro-vitamin K1, which indicates that vitamin K plays potential physiological roles outside of the realm of carboxylation. The hVKORL1 turnover rate for vitamin K 2,3-epoxide reductase activity is significantly slower than for hVKOR, EC 1.1.4.1. the physiological role for VKORL1 reduction of vitamin K 2,3-epoxide is minimal Homo sapiens