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Literature summary for 1.17.4.5 extracted from

  • Mukharji, I.; Silverman, R.B.
    Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone (1985), Proc. Natl. Acad. Sci. USA, 82, 2713-2717.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
3-[(3-cholamidopropyl)-dimethyl-ammonio]1-propane sulfonate CHAPS, activation Bos taurus
dithiothreitol non-physiological cofactor Bos taurus

General Stability

General Stability Organism
high ionic strength inactivates during purification Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
glycerol concentrations up to 30% v/v inhibit enzyme activity up to 88% Bos taurus
additional information not inhibited by warfarin Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Bos taurus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
12400
-
2 * 12400, SDS-PAGE Bos taurus
25000
-
gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol Bos taurus
-
2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.235
-
-
Bos taurus

Storage Stability

Storage Stability Organism
-70°C, microsomal preparation, stable for months Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol i.e. vitamin K 2,3-epoxide Bos taurus 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol i.e. 3-hydroxy-2,3-dihydro-vitamin K ?
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
Bos taurus 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol
-
?

Subunits

Subunits Comment Organism
dimer 2 * 12400, SDS-PAGE Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
-
Bos taurus

Cofactor

Cofactor Comment Organism Structure
additional information 2-mercaptoethanol, reduced GSH, 1,2-ethanediol, or reduced lipoic acid are ineffective as cofactors Bos taurus