Cloned (Comment) | Organism |
---|---|
expression of mutant enzymes in Sf9 insect cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C132A | mutation eliminates enzymatic activity in conversion of vitamin K to vitamin K hydroquinone | Homo sapiens |
C135A | mutation eliminates enzymatic activity in conversion of vitamin K to vitamin K hydroquinone | Homo sapiens |
C16A | about 85% of wild-type activity in conversion of vitamin K to vitamin K hydroquinone. Mutant enzyme retains 40% of the wild-type activityin conversion of vitamin K to vitamin K hydroquinone | Homo sapiens |
C43A | about 75% of wild-type activity in conversion of vitamin K to vitamin K hydroquinone. Mutant enzyme retains 25% of the wild-type activityin conversion of vitamin K to vitamin K hydroquinone | Homo sapiens |
C43A/C51A | about 50% of wild-type activity in conversion of vitamin K to vitamin K hydroquinone. The deletion mutant enzyme retains 85% of the wild-type activity in the conversion of vitamin K 2,3-epoxide to vitamin K | Homo sapiens |
C51A | mutant enzyme retains essentially wild-type activity in conversion of vitamin K to vitamin K hydroquinone | Homo sapiens |
C85A | about 55% of wild-type activity in conversion of vitamin K to vitamin K hydroquinone. Mutant enzyme retains 105% of the wild-type activityin conversion of vitamin K to vitamin K hydroquinone | Homo sapiens |
C96A | about 50% of wild-type activity in conversion of vitamin K to vitamin K hydroquinone. Mutant enzyme retains 40% of the wild-type activityin conversion of vitamin K to vitamin K hydroquinone | Homo sapiens |
DELTAC43-C51 | about 50% of wild-type activity in conversion of vitamin K to vitamin K hydroquinone. The deletion mutant enzyme retains 112% of the wild-type activity in the conversion of vitamin K 2,3-epoxide to vitamin K | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
warfarin | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | integral membrane enzyme of the endoplasmic reticulum | Homo sapiens | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BQB6 | vitamin K epoxide reductase complex subunit 1 | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + 1,4-dithiothreitol | - |
Homo sapiens | vitamin K + oxidized dithiothreitol + H2O | - |
? | |
vitamin K + 1,4-dithiothreitol | - |
Homo sapiens | vitamin K hydroquinone + oxidized dithiothreitol + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
VKOR | - |
Homo sapiens |