Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ATI-5900 | very poor VKORC1 inhibitor | Canis lupus familiaris | |
ATI-5900 | very poor VKORC1 inhibitor | Homo sapiens | |
tecarfarin | ATI-5923, non-competitive inhibitor of VKORC1 | Canis lupus familiaris | |
tecarfarin | ATI-5923, non-competitive inhibitor of VKORC1 | Homo sapiens | |
warfarin | non-competitive inhibitor of VKORC1 | Canis lupus familiaris | |
warfarin | non-competitive inhibitor of VKORC1 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
vitamin K 2,3-epoxide + dithiothreitol | - |
Homo sapiens | vitamin K + oxidized dithiothreitol | - |
? | |
vitamin K 2,3-epoxide + dithiothreitol | - |
Canis lupus familiaris | vitamin K + oxidized dithiothreitol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
vitamin K epoxide reductase | - |
Homo sapiens |
vitamin K epoxide reductase | - |
Canis lupus familiaris |
VKOR | - |
Homo sapiens |
VKOR | - |
Canis lupus familiaris |
VKORC1 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00067 | - |
in 250 mM potassium phosphate, 500 mM potassium chloride, 20% (v/v) glycerol and 0.75% (w/v) CHAPS at pH 7.85 and 25°C | Homo sapiens | tecarfarin | |
0.00084 | - |
in 250 mM potassium phosphate, 500 mM potassium chloride, 20% (v/v) glycerol and 0.75% (w/v) CHAPS at pH 7.85 and 25°C | Homo sapiens | warfarin | |
0.27 | - |
in 250 mM potassium phosphate, 500 mM potassium chloride, 20% (v/v) glycerol and 0.75% (w/v) CHAPS at pH 7.85 and 25°C | Homo sapiens | ATI-5900 |