Protein Variants | Comment | Organism |
---|---|---|
Y139C | warfarin-resistant mutant | Rattus norvegicus |
Y139F | warfarin-resistant mutant | Rattus norvegicus |
Y139S | warfarin-resistant mutant | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Deriphat 160 | Deriphat 160 is an efficient detergent for the solubilization of VKOR, but the enzyme is inactive in its presence | Rattus norvegicus | |
potassium cholate | 0.5% (w/v) potassium cholate releases nearly 60% of the VKOR activity originally present in intact microsomes | Rattus norvegicus | |
Triton X-100 | VKOR activity is dramatically decreased in Triton X-100 | Rattus norvegicus | |
warfarin | i.e. 3-(alpha-acetonylbenzyl)-4-hydroxycoumarin, VKOR is highly sensitive to inhibition by warfarin | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
18000 | - |
SDS-PAGE | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
DE52 cellulose column chromatography, Bio-Gel P-100 gel filtration, and agarose-glutathione column chromatography | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
vitamin K 2,3-epoxide + dithiothreitol | - |
Rattus norvegicus | vitamin K + oxidized dithiothreitol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
vitamin K epoxide reductase | - |
Rattus norvegicus |
VKOR | - |
Rattus norvegicus |