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Literature summary for 1.17.4.4 extracted from

  • Tie, J.K.; Stafford, D.W.
    Structure and function of vitamin K epoxide reductase (2008), Vitam. Horm., 78, 103-130.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
Y139C warfarin-resistant mutant Rattus norvegicus
Y139F warfarin-resistant mutant Rattus norvegicus
Y139S warfarin-resistant mutant Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Deriphat 160 Deriphat 160 is an efficient detergent for the solubilization of VKOR, but the enzyme is inactive in its presence Rattus norvegicus
potassium cholate 0.5% (w/v) potassium cholate releases nearly 60% of the VKOR activity originally present in intact microsomes Rattus norvegicus
Triton X-100 VKOR activity is dramatically decreased in Triton X-100 Rattus norvegicus
warfarin i.e. 3-(alpha-acetonylbenzyl)-4-hydroxycoumarin, VKOR is highly sensitive to inhibition by warfarin Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
18000
-
SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
DE52 cellulose column chromatography, Bio-Gel P-100 gel filtration, and agarose-glutathione column chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
vitamin K 2,3-epoxide + dithiothreitol
-
Rattus norvegicus vitamin K + oxidized dithiothreitol
-
?

Synonyms

Synonyms Comment Organism
vitamin K epoxide reductase
-
Rattus norvegicus
VKOR
-
Rattus norvegicus