Literature summary for 1.17.4.4 extracted from

Larramendy-Gozalo, C.; Yang, J.Q.; Verstuyft, C.; Bodin, L.; Dubert, L.; Zhang, Y.; Xu, C.; Fan, L.; Jaillon, P.; Becquemont, L.
Genetic polymorphism of vitamin K epoxide reductase (VKORC1) 1173C>T in a Chinese and a Caucasian population (2006), Basic Clin. Pharmacol. Toxicol., 98, 611-613.

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Protein Variants

Protein Variants	Comment	Organism
C1173T	natural genetic polymorphism of the enzyme in a Chinese and a Caucasian population, genotyping, the exchange for T at position 1173 in asian patients results in a phenotype with higher sensitivity to oral anticoagulants, overview	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	vitamin K epoxide reductase is the enzyme responsible for the recycling of vitamin K 2,3-epoxide to vitamin K hydroquinone, a cofactor that is essential for the synthesis of several blood coagulation factors	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9BQB6	VKORC1 subunit 1; Chinese and Causasian men, gene VKORC1	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	vitamin K epoxide reductase is the enzyme responsible for the recycling of vitamin K 2,3-epoxide to vitamin K hydroquinone, a cofactor that is essential for the synthesis of several blood coagulation factors	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
vitamin K epoxide reductase	-	Homo sapiens
VKORC1	-	Homo sapiens

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Release 2023.1 (January 2023)