Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.17.4.4 extracted from

  • Wallin, R.; Sane, D.C.; Hutson, S.M.
    Vitamin K 2,3-epoxide reductase and the vitamin K-dependent gamma-carboxylation system (2003), Thromb. Res., 108, 221-226.
    View publication on PubMed
Search for more literature for 1.17.4.4

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
vitamin K1 2,3-epoxide + dithiothreitol Rattus norvegicus vitamin K is an essential cofactor for post-translational gamma-carboxylation of vitamin K-dependent coagulation factors. The modification is carried out by a system of integral proteins of the endoplasmic reticulum membrane where the warfarin sensitive vitamin K 2,3-epoxide reductase (VKOR) produces the reduced hydroquinone form of vitamin K needed by the gamma-carboxylase as the active cofactor. VKOR is the rate-limiting step in the system vitamin K1 + oxidized dithiothreitol
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
vitamin K1 2,3-epoxide + dithiothreitol vitamin K is an essential cofactor for post-translational gamma-carboxylation of vitamin K-dependent coagulation factors. The modification is carried out by a system of integral proteins of the endoplasmic reticulum membrane where the warfarin sensitive vitamin K 2,3-epoxide reductase (VKOR) produces the reduced hydroquinone form of vitamin K needed by the gamma-carboxylase as the active cofactor. VKOR is the rate-limiting step in the system Rattus norvegicus vitamin K1 + oxidized dithiothreitol
-
 ?

Synonyms

Synonyms Comment Organism
VKOR
-
 Rattus norvegicus
warfarin sensitive vitamin K 2,3-epoxide reductase
-
 Rattus norvegicus