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Literature summary for 1.17.4.4 extracted from
- Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition (1978), Biochemistry, 17, 1371-1377.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | - |
Rattus norvegicus |  |
| lipoic acid | - |
Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| coumarin anticoagulants | - |
Rattus norvegicus | |
| Difenacoum | - |
Rattus norvegicus | |
| warfarin | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
| microsome | integral membrane protein | Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | Rattus norvegicus | - |
2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | - |
? | |
| 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | Rattus norvegicus Holtzman | - |
2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Holtzman strain | - |
| Rattus norvegicus | - |
warfarin-resistant rat | - |
| Rattus norvegicus Holtzman | - |
Holtzman strain | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
Rattus norvegicus | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | - |
? | |
| 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
Rattus norvegicus Holtzman | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | - |
? | |
| vitamin K 2,3-epoxide + dithiothreitol | - |
Rattus norvegicus | vitamin K + oxidized dithiothreitol | - |
? | |
| vitamin K 2,3-epoxide + dithiothreitol | - |
Rattus norvegicus Holtzman | vitamin K + oxidized dithiothreitol | - |
? | |
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