Inhibitors | Comment | Organism | Structure |
---|---|---|---|
gemcitabine | i.e. 2',2'-difluoro-2'-deoxycytidine, dFdC, a deoxycytidine analogue, very active drug against solid tumors, the RNR inactivation is reductant-dependent for R1 subunit, but reductant-independent for the R2 subunit, R1 inactivation is the most favorable mechanism responsible for the drug's cytotoxicity, overview, binding and inhibition mechanism including the formation of a Cys225-Cys462 disulfide bridge, detailed overview | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
More | ribonucleotide diphosphate reductase class Ia | Escherichia coli |
ribonucleotide diphosphate reductase | - |
Escherichia coli |
RNR | - |
Escherichia coli |
RNR class Ia | - |
Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics with gemcitabine | Escherichia coli |