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Literature summary for 1.17.4.1 extracted from

  • Panosa, A.; Roca, I.; Gibert, I.
    Ribonucleotide reductases of Salmonella typhimurium: transcriptional regulation and differential role in pathogenesis (2010), PLoS ONE, 5, e11328.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
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serovar Typhimurium, inside RAW264.7 macrophages or HeLa cells
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Synonyms

Synonyms Comment Organism
class Ib RNR
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Salmonella enterica subsp. enterica serovar Typhimurium

General Information

General Information Comment Organism
additional information transcriptional regulation of RNR classes as well as their differential function during infection of macrophage and epithelial cells, overview Salmonella enterica subsp. enterica serovar Typhimurium
physiological function role of RNRs during infection of macrophages and epithelial cells, overview. Class Ia to be mainly responsible for deoxyribonucleotide production during invasion and proliferation inside macrophages and epithelial cells, while class Ib RNR is not. Class Ib RNR may contribute to deoxyribonucleotide synthesis by means of both an NrdR and a Fur-dependent derepression of nrdHIEF due to hydrogen peroxide production and DNA damage associated with the oxidative burst, thus helping to overcome the host defenses Salmonella enterica subsp. enterica serovar Typhimurium