Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
Application | Comment | Organism |
---|---|---|
drug development | the enzyme is an important therapeutic target for anticancer drugs | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of His6-tagged subunits hRRM1 and hRRM2 in Escherichia coli strain BL21(DE3) | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-furan-3-ylbenzaldehyde N-(4-hydroxyphenyl)thiosemicarbazone | - |
Homo sapiens | |
2-furan-3-ylbenzaldehyde N-phenylthiosemicarbazone | - |
Homo sapiens | |
2-hydroxybenzaldehyde N-(4-chlorophenyl)thiosemicarbazone | - |
Homo sapiens | |
2-hydroxybenzaldehyde N-phenylthiosemicarbazone | - |
Homo sapiens | |
2-thiophen-2-ylbenzaldehyde N-(4-chlorophenyl)thiosemicarbazone | - |
Homo sapiens | |
2-thiophen-2-ylbenzaldehyde N-phenylthiosemicarbazone | - |
Homo sapiens | |
4-hydroxy-3-methoxybenzaldehyde N-(4-chlorophenyl)thiosemicarbazone | - |
Homo sapiens | |
4-hydroxy-3-methoxybenzaldehyde N-phenylthiosemicarbazone | - |
Homo sapiens | |
4-hydroxybenzaldehyde N-(2-chlorophenyl)thiosemicarbazone | - |
Homo sapiens | |
4-hydroxybenzaldehyde N-(2-hydroxyphenyl)thiosemicarbazone | - |
Homo sapiens | |
4-hydroxybenzaldehyde N-(2-methoxyphenyl)thiosemicarbazone | - |
Homo sapiens | |
4-hydroxybenzaldehyde N-(2-methylphenyl)thiosemicarbazone | - |
Homo sapiens | |
4-hydroxybenzaldehyde N-(2-nitrophenyl)thiosemicarbazone | - |
Homo sapiens | |
4-hydroxybenzaldehyde N-(3-chlorophenyl)thiosemicarbazone | - |
Homo sapiens | |
4-hydroxybenzaldehyde N-(3-hydroxyphenyl)thiosemicarbazone | - |
Homo sapiens | |
4-hydroxybenzaldehyde N-(3-methylphenyl)thiosemicarbazone | - |
Homo sapiens | |
4-hydroxybenzaldehyde N-(4-chlorophenyl)thiosemicarbazone | - |
Homo sapiens | |
4-hydroxybenzaldehyde N-(4-hydroxyphenyl)thiosemicarbazone | - |
Homo sapiens | |
4-hydroxybenzaldehyde N-(4-methylphenyl)thiosemicarbazone | - |
Homo sapiens | |
4-hydroxybenzaldehyde N-(4-nitrophenyl)thiosemicarbazone | - |
Homo sapiens | |
4-hydroxybenzaldehyde N-phenylthiosemicarbazone | - |
Homo sapiens | |
Hydroxyurea | - |
Homo sapiens | |
additional information | synthesis and ribonucleotide reductase inhibitory activity of thiosemicarbazones, overview | Homo sapiens | |
triapine | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant His6-tagged subunits hRRM1 and hRRM2 from Escherichia coli strain BL21(DE3) | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | CDP as substrate resulting information of product dCDP | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | 1:1 complex of two homodimeric subunits, hRRM1 and hRRM2 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ribonucleotide reductase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.014 | - |
pH 7.2, 37°C | Homo sapiens | 4-hydroxybenzaldehyde N-(4-methylphenyl)thiosemicarbazone | |
0.029 | - |
pH 7.2, 37°C | Homo sapiens | 4-hydroxybenzaldehyde N-(3-chlorophenyl)thiosemicarbazone | |
0.029 | - |
pH 7.2, 37°C | Homo sapiens | 4-hydroxybenzaldehyde N-(2-hydroxyphenyl)thiosemicarbazone | |
0.029 | - |
pH 7.2, 37°C | Homo sapiens | 4-hydroxybenzaldehyde N-(3-hydroxyphenyl)thiosemicarbazone | |
0.03 | - |
pH 7.2, 37°C | Homo sapiens | 4-hydroxybenzaldehyde N-(3-methylphenyl)thiosemicarbazone | |
0.037 | - |
pH 7.2, 37°C | Homo sapiens | 4-hydroxybenzaldehyde N-(2-methylphenyl)thiosemicarbazone | |
0.039 | - |
pH 7.2, 37°C | Homo sapiens | 4-hydroxybenzaldehyde N-(2-nitrophenyl)thiosemicarbazone | |
0.042 | - |
above, pH 7.2, 37°C | Homo sapiens | 4-hydroxybenzaldehyde N-(2-methoxyphenyl)thiosemicarbazone | |
0.043 | - |
pH 7.2, 37°C | Homo sapiens | 4-hydroxybenzaldehyde N-(4-hydroxyphenyl)thiosemicarbazone | |
0.045 | - |
pH 7.2, 37°C | Homo sapiens | 4-hydroxybenzaldehyde N-(4-nitrophenyl)thiosemicarbazone | |
0.047 | - |
pH 7.2, 37°C | Homo sapiens | 4-hydroxybenzaldehyde N-(2-chlorophenyl)thiosemicarbazone | |
0.242 | - |
pH 7.2, 37°C | Homo sapiens | 4-hydroxybenzaldehyde N-phenylthiosemicarbazone | |
0.287 | - |
pH 7.2, 37°C | Homo sapiens | 4-hydroxybenzaldehyde N-(4-chlorophenyl)thiosemicarbazone | |
0.5 | - |
above, pH 7.2, 37°C | Homo sapiens | 2-hydroxybenzaldehyde N-phenylthiosemicarbazone | |
0.5 | - |
above, pH 7.2, 37°C | Homo sapiens | 2-hydroxybenzaldehyde N-(4-chlorophenyl)thiosemicarbazone | |
0.5 | - |
above, pH 7.2, 37°C | Homo sapiens | 4-hydroxy-3-methoxybenzaldehyde N-phenylthiosemicarbazone | |
0.5 | - |
above, pH 7.2, 37°C | Homo sapiens | 4-hydroxy-3-methoxybenzaldehyde N-(4-chlorophenyl)thiosemicarbazone | |
0.5 | - |
above, pH 7.2, 37°C | Homo sapiens | 2-furan-3-ylbenzaldehyde N-phenylthiosemicarbazone | |
0.5 | - |
above, pH 7.2, 37°C | Homo sapiens | 2-furan-3-ylbenzaldehyde N-(4-hydroxyphenyl)thiosemicarbazone | |
0.5 | - |
above, pH 7.2, 37°C | Homo sapiens | 2-thiophen-2-ylbenzaldehyde N-phenylthiosemicarbazone | |
0.5 | - |
above, pH 7.2, 37°C | Homo sapiens | 2-thiophen-2-ylbenzaldehyde N-(4-chlorophenyl)thiosemicarbazone |