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Literature summary for 1.17.4.1 extracted from

  • Krishnan, K.; Prathiba, K.; Jayaprakash, V.; Basu, A.; Mishra, N.; Zhou, B.; Hu, S.; Yen, Y.
    Synthesis and ribonucleotide reductase inhibitory activity of thiosemicarbazones (2008), Bioorg. Med. Chem. Lett., 18, 6248-6250.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ATP
-
Homo sapiens

Application

Application Comment Organism
drug development the enzyme is an important therapeutic target for anticancer drugs Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of His6-tagged subunits hRRM1 and hRRM2 in Escherichia coli strain BL21(DE3) Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-furan-3-ylbenzaldehyde N-(4-hydroxyphenyl)thiosemicarbazone
-
Homo sapiens
2-furan-3-ylbenzaldehyde N-phenylthiosemicarbazone
-
Homo sapiens
2-hydroxybenzaldehyde N-(4-chlorophenyl)thiosemicarbazone
-
Homo sapiens
2-hydroxybenzaldehyde N-phenylthiosemicarbazone
-
Homo sapiens
2-thiophen-2-ylbenzaldehyde N-(4-chlorophenyl)thiosemicarbazone
-
Homo sapiens
2-thiophen-2-ylbenzaldehyde N-phenylthiosemicarbazone
-
Homo sapiens
4-hydroxy-3-methoxybenzaldehyde N-(4-chlorophenyl)thiosemicarbazone
-
Homo sapiens
4-hydroxy-3-methoxybenzaldehyde N-phenylthiosemicarbazone
-
Homo sapiens
4-hydroxybenzaldehyde N-(2-chlorophenyl)thiosemicarbazone
-
Homo sapiens
4-hydroxybenzaldehyde N-(2-hydroxyphenyl)thiosemicarbazone
-
Homo sapiens
4-hydroxybenzaldehyde N-(2-methoxyphenyl)thiosemicarbazone
-
Homo sapiens
4-hydroxybenzaldehyde N-(2-methylphenyl)thiosemicarbazone
-
Homo sapiens
4-hydroxybenzaldehyde N-(2-nitrophenyl)thiosemicarbazone
-
Homo sapiens
4-hydroxybenzaldehyde N-(3-chlorophenyl)thiosemicarbazone
-
Homo sapiens
4-hydroxybenzaldehyde N-(3-hydroxyphenyl)thiosemicarbazone
-
Homo sapiens
4-hydroxybenzaldehyde N-(3-methylphenyl)thiosemicarbazone
-
Homo sapiens
4-hydroxybenzaldehyde N-(4-chlorophenyl)thiosemicarbazone
-
Homo sapiens
4-hydroxybenzaldehyde N-(4-hydroxyphenyl)thiosemicarbazone
-
Homo sapiens
4-hydroxybenzaldehyde N-(4-methylphenyl)thiosemicarbazone
-
Homo sapiens
4-hydroxybenzaldehyde N-(4-nitrophenyl)thiosemicarbazone
-
Homo sapiens
4-hydroxybenzaldehyde N-phenylthiosemicarbazone
-
Homo sapiens
Hydroxyurea
-
Homo sapiens
additional information synthesis and ribonucleotide reductase inhibitory activity of thiosemicarbazones, overview Homo sapiens
triapine
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His6-tagged subunits hRRM1 and hRRM2 from Escherichia coli strain BL21(DE3) Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information CDP as substrate resulting information of product dCDP Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
tetramer 1:1 complex of two homodimeric subunits, hRRM1 and hRRM2 Homo sapiens

Synonyms

Synonyms Comment Organism
ribonucleotide reductase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.014
-
pH 7.2, 37°C Homo sapiens 4-hydroxybenzaldehyde N-(4-methylphenyl)thiosemicarbazone
0.029
-
pH 7.2, 37°C Homo sapiens 4-hydroxybenzaldehyde N-(3-chlorophenyl)thiosemicarbazone
0.029
-
pH 7.2, 37°C Homo sapiens 4-hydroxybenzaldehyde N-(2-hydroxyphenyl)thiosemicarbazone
0.029
-
pH 7.2, 37°C Homo sapiens 4-hydroxybenzaldehyde N-(3-hydroxyphenyl)thiosemicarbazone
0.03
-
pH 7.2, 37°C Homo sapiens 4-hydroxybenzaldehyde N-(3-methylphenyl)thiosemicarbazone
0.037
-
pH 7.2, 37°C Homo sapiens 4-hydroxybenzaldehyde N-(2-methylphenyl)thiosemicarbazone
0.039
-
pH 7.2, 37°C Homo sapiens 4-hydroxybenzaldehyde N-(2-nitrophenyl)thiosemicarbazone
0.042
-
above, pH 7.2, 37°C Homo sapiens 4-hydroxybenzaldehyde N-(2-methoxyphenyl)thiosemicarbazone
0.043
-
pH 7.2, 37°C Homo sapiens 4-hydroxybenzaldehyde N-(4-hydroxyphenyl)thiosemicarbazone
0.045
-
pH 7.2, 37°C Homo sapiens 4-hydroxybenzaldehyde N-(4-nitrophenyl)thiosemicarbazone
0.047
-
pH 7.2, 37°C Homo sapiens 4-hydroxybenzaldehyde N-(2-chlorophenyl)thiosemicarbazone
0.242
-
pH 7.2, 37°C Homo sapiens 4-hydroxybenzaldehyde N-phenylthiosemicarbazone
0.287
-
pH 7.2, 37°C Homo sapiens 4-hydroxybenzaldehyde N-(4-chlorophenyl)thiosemicarbazone
0.5
-
above, pH 7.2, 37°C Homo sapiens 2-hydroxybenzaldehyde N-phenylthiosemicarbazone
0.5
-
above, pH 7.2, 37°C Homo sapiens 2-hydroxybenzaldehyde N-(4-chlorophenyl)thiosemicarbazone
0.5
-
above, pH 7.2, 37°C Homo sapiens 4-hydroxy-3-methoxybenzaldehyde N-phenylthiosemicarbazone
0.5
-
above, pH 7.2, 37°C Homo sapiens 4-hydroxy-3-methoxybenzaldehyde N-(4-chlorophenyl)thiosemicarbazone
0.5
-
above, pH 7.2, 37°C Homo sapiens 2-furan-3-ylbenzaldehyde N-phenylthiosemicarbazone
0.5
-
above, pH 7.2, 37°C Homo sapiens 2-furan-3-ylbenzaldehyde N-(4-hydroxyphenyl)thiosemicarbazone
0.5
-
above, pH 7.2, 37°C Homo sapiens 2-thiophen-2-ylbenzaldehyde N-phenylthiosemicarbazone
0.5
-
above, pH 7.2, 37°C Homo sapiens 2-thiophen-2-ylbenzaldehyde N-(4-chlorophenyl)thiosemicarbazone