Application | Comment | Organism |
---|---|---|
additional information | the enzyme is a target for drug design against the parasite | Leishmania donovani |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
quercetin | i.e. 3,3',4',5,7-pentahydroxyflavone, isolated from air-dried powdered leaves of Vitex negundo, a lipophilic metal chelator, that interferes with the parasite's iron metabolism inhibiting Fe2+ acquisition from an endogenous source, combination of quercetin with serum albumin increases its bioavailability, the inhibitor causes deprivation of the enzyme of iron which in turn destabilized the critical tyrosyl radical required for its catalysing activity | Leishmania donovani |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | - |
Leishmania donovani |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CDP + thioredoxin | Leishmania donovani | - |
2'-deoxyCDP + thioredoxin disulfide + H2O | - |
? | |
CDP + thioredoxin | Leishmania donovani MHOM/IN/1983/AG83 | - |
2'-deoxyCDP + thioredoxin disulfide + H2O | - |
? | |
ribonucleoside diphosphate + thioredoxin | Leishmania donovani | the enzyme catalyses the rate-limiting step of DNA synthesis in the pathogen | 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O | - |
? | |
ribonucleoside diphosphate + thioredoxin | Leishmania donovani MHOM/IN/1983/AG83 | the enzyme catalyses the rate-limiting step of DNA synthesis in the pathogen | 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania donovani | - |
- |
- |
Leishmania donovani MHOM/IN/1983/AG83 | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amastigote | - |
Leishmania donovani | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CDP + thioredoxin | - |
Leishmania donovani | 2'-deoxyCDP + thioredoxin disulfide + H2O | - |
? | |
CDP + thioredoxin | - |
Leishmania donovani MHOM/IN/1983/AG83 | 2'-deoxyCDP + thioredoxin disulfide + H2O | - |
? | |
ribonucleoside diphosphate + thioredoxin | the enzyme catalyses the rate-limiting step of DNA synthesis in the pathogen | Leishmania donovani | 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O | - |
? | |
ribonucleoside diphosphate + thioredoxin | classical pathway via tyrosyl radical | Leishmania donovani | 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O | - |
? | |
ribonucleoside diphosphate + thioredoxin | the enzyme catalyses the rate-limiting step of DNA synthesis in the pathogen | Leishmania donovani MHOM/IN/1983/AG83 | 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O | - |
? | |
ribonucleoside diphosphate + thioredoxin | classical pathway via tyrosyl radical | Leishmania donovani MHOM/IN/1983/AG83 | 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thioredoxin | - |
Leishmania donovani |