Literature summary for 1.17.4.1 extracted from

Avolio, T.M.; Lee, Y.; Feng, N.; Xiong, K.; Jin, H.; Wang, M.; Vassilakos, A.; Wright, J.; Young, A.
RNA interference targeting the R2 subunit of ribonucleotide reductase inhibits growth of tumor cells in vitro and in vivo (2007), Anticancer Drugs, 18, 377-388.

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Protein Variants

Protein Variants	Comment	Organism
additional information	expression of subunit R2 siRNA 1284, targeting the AA(N19) sequence motif, inhibits R2 expression and active enzyme complex formation in different cell lines, it also inhibits cell growth and proloferation in vitro by blocking in the S-phase of the cell cycle, overview	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
78000	-	2 * 160000, subunit R1, + 2 * 78000, subunit R2, the catalytic active enzyme forms a dimer of homodimers	Homo sapiens
160000	-	2 * 160000, subunit R1, + 2 * 78000, subunit R2, the catalytic active enzyme forms a dimer of homodimers	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ribonucleoside 5'-diphosphate + thioredoxin	Homo sapiens	the essential enzyme catalyzes the rate-limiting step in dNTP production for DNA synthesis	2'-deoxyribonuleoside 5'-diphosphate + thioredoxin disulfide + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-2058 cell	-	Homo sapiens	-
A-498 cell	-	Homo sapiens	-
HT-29 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ribonucleoside 5'-diphosphate + thioredoxin	-	Homo sapiens	2'-deoxyribonuleoside 5'-diphosphate + thioredoxin disulfide + H2O	-	?
ribonucleoside 5'-diphosphate + thioredoxin	the essential enzyme catalyzes the rate-limiting step in dNTP production for DNA synthesis	Homo sapiens	2'-deoxyribonuleoside 5'-diphosphate + thioredoxin disulfide + H2O	-	?

Subunits

Subunits	Comment	Organism
tetramer	2 * 160000, subunit R1, + 2 * 78000, subunit R2, the catalytic active enzyme forms a dimer of homodimers	Homo sapiens

Synonyms

Synonyms	Comment	Organism
ribonucleotide reductase	-	Homo sapiens
RNR	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
thioredoxin	-	Homo sapiens

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Release 2023.1 (January 2023)