Literature summary for 1.17.4.1 extracted from

Schroeder, P.; Voevodskaya, N.; Klotz, L.O.; Brenneisen, P.; Graslund, A.; Sies, H.
Loss of the tyrosyl radical in mouse ribonucleotide reductase by (-)-epicatechin (2005), Biochem. Biophys. Res. Commun., 326, 614-617.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(-)-epicatechin	interacts with the R2 protein, leading to a loss of the tyrosyl radical EPR signal. Proliferation of cells exposed to (-)-epicatechin is downregulated, and deoxyribonucleotide levels are significantly diminished	Homo sapiens
(-)-epicatechin	interacts with the R2 protein, leading to a loss of the tyrosyl radical EPR signal. Proliferation of cells exposed to (-)-epicatechin is downregulated, and deoxyribonucleotide levels are significantly diminished	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	recombinant enzyme	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
carcinoma cell	squamous	Homo sapiens	-
keratinocyte	-	Homo sapiens	-

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Release 2023.1 (January 2023)