Literature summary for 1.17.4.1 extracted from

Fitzgerald, G.B.; Rosowsky, A.; Wick, M.M.
Inhibition of ribonucleotide reductase by naturally occurring quinols from spores of Agaricus bisporus (1984), Biochem. Biophys. Res. Commun., 120, 1008-1014.

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Inhibitors

Inhibitors	Comment	Organism	Structure
gamma-L-Glutaminyl-4-hydroxybenzene	naturally occuring quinol from spores of Agaricus bisporus, 0.76 mM, 50% inhibition	Mus musculus
glutaminyl-3,4-dihydroxybenzene	1.23 mM, 50% inhibition	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
L-1210 cell	L1210 cells resistant to specific ribonucleotide reductase inhibitors	Mus musculus	-
L-cell	cell line	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ribonucleoside diphosphate + reduced thioredoxin	-	Mus musculus	2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O	-	ir

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Release 2023.1 (January 2023)