Literature summary for 1.17.4.1 extracted from

Cory, J.G.; Rey, D.A.; Carter, G.L.; Bacon, P.E.
Nucleoside 5'-diphosphates as effectors of mammalian ribonucleotide reductase (1985), J. Biol. Chem., 260, 12001-12007.

Search for more literature for 1.17.4.1

Activating Compound

Activating Compound	Comment	Organism	Structure
adenyl-5'-yl-imidodiphosphate	can replace ATP as activator of CDP and UDP reduction	Mus musculus
ADP	-	Mus musculus
dGDP	40% less effective than dGTP	Mus musculus
dGTP	activation of ADP reduction	Mus musculus
additional information	overview: nucleoside 5'-diphosphates as effectors of mammalian ribonucleotide reductase	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
dATP	inhibition of CDP reduction; inhibition of CDP, UDP, GDP and ADP reduction; noncompetitive inhibition vs. ADP, GDP and CDP	Mus musculus
dGTP	inhibition of GDP reduction	Mus musculus
dTTP	inhibition of ADP- CDP- and UDP reduction	Mus musculus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
additional information	model of enzyme regulation by nucleoside 5'-triphosphates	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	Ehrlich ascites tumor cells	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Ehrlich ascites carcinoma cell	-	Mus musculus	-
L-1210 cell	-	Mus musculus	-
L-cell	cell line	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ribonucleoside diphosphate + reduced thioredoxin	-	Mus musculus	2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O	-	ir

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Release 2023.1 (January 2023)