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Literature summary for 1.17.4.1 extracted from

  • carter, G.L.; Cory, J.G.
    Selective resistance of L1210 cell lines to inhibitors directed at the subunits of ribonucleotide reductase (1989), Adv. Enzyme Regul., 29, 123-139.
    View publication on PubMed
Search for more literature for 1.17.4.1

Inhibitors

Inhibitors Comment Organism Structure
additional information L1210 cells with resistance to specific nucleotide reductase inhibitors Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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 wild-type and reductase inhibitor resistant L1210 cell line
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Source Tissue

Source Tissue Comment Organism Textmining
L-1210 cell L1210 cells resistant to specific ribonucleotide reductase inhibitors Mus musculus
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L-cell cell line Mus musculus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 extracts from hydroxyurea resistant cell line HU-7 exhibit a 13fold higher ADP reductase activity and a 5fold higher CDP reductase activity when compared to wild-type Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ribonucleoside diphosphate + reduced thioredoxin
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 Mus musculus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
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 ir