Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-Formylisoquinoline thiosemicarbazone | 0.0006 mM, 81% inhibition, 0.1 mM desferal reverses inhibition | Mus musculus | |
2,3-Dihydro-1H-pyrazolo[2,3-a]imidazole | - |
Mus musculus | |
3,5-diamino-1H-1,2,4-triazole | 2 mM, 41% inhibition, presence of 0.1 mM desferal potentiates inhibition; trivial name guanazole | Mus musculus | |
4-Methyl-5-amino-1-formylisoquinoline thiosemicarbazone | 0.0003 mM, 93% inhibition, 0.1 mM desferal reverses inhibition | Mus musculus | |
Hydroxyurea | 2 mM, 93% inhibition, presence of 0.1 mM desferal potentiates inhibition | Mus musculus | |
additional information | inhibition of reductase by hydroxyurea, guanazole and pyrazolo-imidazole is potentiated by iron-chelating agents e.g. EDTA, desferrioxamine mesylate and 8-hydroxyquinoline, inhibition by 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone and 1-formylisoquinoline thiosemicarbazone is reversed by iron chelating agents | Mus musculus | |
Periodate-oxidized inosine | - |
Mus musculus | |
pyrazoloimidazol | 2 mM, 79% inhibition, presence of 0.1 mM desferal potentiates inhibition, inhibits the non-heme iron subunit | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
Ehrlich ascites tumor cells | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Ehrlich ascites carcinoma cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ribonucleoside diphosphate + reduced thioredoxin | - |
Mus musculus | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
ir |