Literature summary for 1.17.3.2 extracted from

Kumar, D.; Kaur, G.; Negi, A.; Kumar, S.; Singh, S.; Kumar, R.
Synthesis and xanthine oxidase inhibitory activity of 5,6-dihydropyrazolo/pyrazolo[1,5-c]quinazoline derivatives (2014), Bioorg. Chem., 57, 57-64 .

Inhibitors

Inhibitors	Comment	Organism
1-(3-(furan-2-yl)-4,5-dihydro-5-(pyridin-4-yl)pyrazol-1-yl)ethanone	-	Bos taurus
2,4-dichloro-6-(2-phenyl-5,6-dihydropyrazolo[1,5-c]quinazolin-5-yl)phenol	-	Bos taurus
2-(3-phenyl-1H-pyrazol-5-yl)aniline	-	Bos taurus
2-(4-chlorophenyl)-5-(3,4-dimethoxyphenyl)-5,6-dihydropyrazolo[1,5-c]quinazoline	-	Bos taurus
2-methoxy-4-(2-phenyl-5,6-dihydropyrazolo[1,5-c]quinazolin-5-yl)phenol	-	Bos taurus
2-phenylpyrazolo[1,5-c]quinazoline	-	Bos taurus
2-[3-(4-chlorophenyl)-1H-pyrazol-5-yl]aniline	-	Bos taurus
4-(2-phenyl-5,6-dihydropyrazolo[1,5-c]quinazolin-5-yl)benzonitrile	-	Bos taurus
4-(2-phenyl-5,6-dihydropyrazolo[1,5-c]quinazolin-5-yl)phenol	-	Bos taurus
4-[2-(4-chlorophenyl)-5,6-dihydropyrazolo[1,5-c]quinazolin-5-yl]-2-methoxyphenol	-	Bos taurus
4-[2-(4-chlorophenyl)-5,6-dihydropyrazolo[1,5-c]quinazolin-5-yl]phenol	-	Bos taurus
5-(1H-indol-3-yl)-2-phenyl-5,6-dihydropyrazolo[1,5-c]quinazoline	-	Bos taurus
5-(2-nitrophenyl)-2-phenyl-5,6-dihydropyrazolo[1,5-c]quinazoline	-	Bos taurus
5-(3,4-dimethoxyphenyl)-2-phenyl-5,6-dihydropyrazolo[1,5-c]quinazoline	-	Bos taurus
5-(3-nitrophenyl)-2-phenyl-5,6-dihydropyrazolo[1,5-c]quinazoline	-	Bos taurus
allopurinol	59.2% inhibition at 0.05 mM	Bos taurus
curcumin	-	Bos taurus
febuxostat	-	Bos taurus
FYX-051	-	Bos taurus
additional information	rational design, synthesis, and xanthine oxidase inhibitory activity of 5,6-dihydropyrazolo/pyrazolo[1,5-c]quinazoline derivatives, molecular docking into the enzyme's active site, structure activity relationship, overview. Mode of binding and important interactions such as hydrogen bonding, Pi-Pi stacking with amino acid residues like Ser876, Thr1010, Phen914, Phe1009, and Phe649 with close proximity to dioxothiomolybdenum	Bos taurus
N-(1-(3-bromophenyl)-3-(naphthalen-2-yl)-3-oxopropyl)acetamide	-	Bos taurus
Y-700	-	Bos taurus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Molybdenum	in dioxothiomolybdenum cofactor	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	P80457	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	-	Bos taurus	-
milk	-	Bos taurus	-

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
22	-	assay at room temperature	Bos taurus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Bos taurus

Cofactor

Cofactor	Comment	Organism	Structure
molybdenum cofactor	dioxothiomolybdenum cofactor	Bos taurus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.011	-	pH 7.5, 22°C	Bos taurus	2,4-dichloro-6-(2-phenyl-5,6-dihydropyrazolo[1,5-c]quinazolin-5-yl)phenol
0.021	-	pH 7.5, 22°C	Bos taurus	5-(3-nitrophenyl)-2-phenyl-5,6-dihydropyrazolo[1,5-c]quinazoline
0.0316	-	pH 7.5, 22°C	Bos taurus	allopurinol
0.0417	-	pH 7.5, 22°C	Bos taurus	2-(3-phenyl-1H-pyrazol-5-yl)aniline
0.0437	-	pH 7.5, 22°C	Bos taurus	5-(3,4-dimethoxyphenyl)-2-phenyl-5,6-dihydropyrazolo[1,5-c]quinazoline