Literature summary for 1.17.3.2 extracted from

Wang, S.; Yan, J.; Wang, J.; Chen, J.; Zhang, T.; Zhao, Y.; Xue, M.
Synthesis of some 5-phenylisoxazole-3-carboxylic acid derivatives as potent xanthine oxidase inhibitors (2010), Eur. J. Med. Chem., 45, 2663-2670.

Search for more literature for 1.17.3.2

Inhibitors

Inhibitors	Comment	Organism	Structure
1-[3-cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid	-	Bos taurus
5-(3-cyano-4-isobutoxyphenyl)isoxazole-3-carboxylic acid	-	Bos taurus
5-(4-benzyloxy-3-cyanophenyl)isoxazole-3-carboxylic acid	-	Bos taurus
5-(4-benzyloxy-3-nitrophenyl)isoxazole-3-carboxylic acid	-	Bos taurus
5-(4-isobutoxy-3-nitrophenyl)isoxazole-3-carboxylic acid	-	Bos taurus
5-[3-cyano-4-(4-methylbenzyloxy)phenyl]-isoxazole-3-carboxylic acid	-	Bos taurus
5-[4-(4-chlorobenzyloxy)-3-cyanophenyl]isoxazole-3-carboxylic acid	-	Bos taurus
5-[4-(4-chlorobenzyloxy)-3-nitrophenyl]isoxazole-3-carboxylic acid	-	Bos taurus
5-[4-(4-methylbenzyloxy)-3-nitrophenyl]isoxazole-3-carboxylic acid	-	Bos taurus
5-[4-(4-tert-butylbenzyloxy)-3-cyanophenyl]isoxazole-3-carboxylic acid	-	Bos taurus
5-[4-(4-tert-butylbenzyloxy)-3-nitrophenyl]isoxazole-3-carboxylic acid	-	Bos taurus
allopurinol	-	Bos taurus
febuxostat	-	Bos taurus
additional information	synthesis of some 5-phenylisoxazole-3-carboxylic acid derivatives as potent xanthine oxidase inhibitors, molecular modeling using 5-(3-cyano-4-isobutoxyphenyl)isoxazole-3-carboxylic acid and febuxostat, overview. No inhibition by 5-[4-(4-methylbenzyloxy)-3-nitrophenyl]isoxazole-3-carboxylic acid and 5-[3-cyano-4-(4-methylbenzyloxy)phenyl]-isoxazole-3-carboxylic acid	Bos taurus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	-	Bos taurus	-	-

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	-	Bos taurus	-
milk	-	Bos taurus	-

Synonyms

Synonyms	Comment	Organism
XOD	-	Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
25	-	assay at	Bos taurus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Bos taurus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00036	-	pH 7.5, 25°C	Bos taurus	5-(3-cyano-4-isobutoxyphenyl)isoxazole-3-carboxylic acid
0.00059	-	pH 7.5, 25°C	Bos taurus	5-(4-benzyloxy-3-cyanophenyl)isoxazole-3-carboxylic acid
0.00063	-	pH 7.5, 25°C	Bos taurus	5-[4-(4-chlorobenzyloxy)-3-cyanophenyl]isoxazole-3-carboxylic acid
0.00097	-	pH 7.5, 25°C	Bos taurus	5-(4-benzyloxy-3-nitrophenyl)isoxazole-3-carboxylic acid
0.001	-	pH 7.5, 25°C	Bos taurus	5-(4-isobutoxy-3-nitrophenyl)isoxazole-3-carboxylic acid
0.00101	-	pH 7.5, 25°C	Bos taurus	5-[4-(4-tert-butylbenzyloxy)-3-cyanophenyl]isoxazole-3-carboxylic acid
0.00283	-	pH 7.5, 25°C	Bos taurus	5-[4-(4-chlorobenzyloxy)-3-nitrophenyl]isoxazole-3-carboxylic acid
0.01275	-	pH 7.5, 25°C	Bos taurus	5-[4-(4-tert-butylbenzyloxy)-3-nitrophenyl]isoxazole-3-carboxylic acid

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Release 2023.1 (January 2023)