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Literature summary for 1.17.3.2 extracted from

  • Rashidi, M.R.; Soruraddin, M.H.; Taherzadeh, F.; Jouyban, A.
    Catalytic activity and stability of xanthine oxidase in aqueous-organic mixtures (2009), Biochemistry (Moscow), 74, 97-101.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
acetonitrile
-
Bos taurus
dimethylformamide highly stimulating Bos taurus
dioxane
-
Bos taurus
ethanol
-
Bos taurus
methanol slightly stimulating Bos taurus
additional information the enzyme activity is stimulated by organic solvents, but the effect is reduced with increasing temperature, from 27°C to 37°C, the inhibitory effects of all organic solvents on the enzyme activity are increased at higher temperature Bos taurus
Propanol slightly stimulating Bos taurus
tetrahydrofuran
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular secreted to milk Bos taurus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Molybdenum a molybdenum-containing enzyme Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
xanthine + O2 + H2O Bos taurus
-
urate + H2O2
-
?

Organic Solvent Stability

Organic Solvent Comment Organism
additional information the enzyme activity is stimulated by organic solvents, but the effect is reduced with increasing temperature, from 27°C to 37°C, the inhibitory effects of all organic solvents on the enzyme activity are increased at higher temperature, dependent on pH, overview Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Bos taurus
-
milk
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
xanthine + O2 + H2O
-
Bos taurus urate + H2O2
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Bos taurus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
27 50
-
Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Bos taurus

pH Range

pH Minimum pH Maximum Comment Organism
6 9
-
Bos taurus

General Information

General Information Comment Organism
metabolism the enzyme plays an important role in the metabolism of many xenobiotics and drugs, such as purines and pyrimidines, mercaptopurine and azathioprine, thiazides, pyrazinamide, and acyclovir Bos taurus
additional information the enzyme also serves as an important biological source of reactive oxygen species that are involved in many pathological processes, such as inflammation, atherosclerosis, cancer, and aging Bos taurus