Literature summary for 1.17.3.2 extracted from

Mukoyoshi, M.; Nishimura, S.; Hoshide, S.; Umeda, S.; Kanou, M.; Taniguchi, K.; Muroga, H.
In vitro drug-drug interaction studies with febuxostat, a novel non-purine selective inhibitor of xanthine oxidase: plasma protein binding, identification of metabolic enzymes and cytochrome P450 inhibition (2008), Xenobiotica, 38, 496-510.

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Inhibitors

Inhibitors	Comment	Organism	Structure
febuxostat	i.e. 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid, a non-purine selective inhibitor of xanthine oxidase, an anti-hyperuricaemia drug with low drug-drug interaction potential in clinical use, in vitro drug-drug interaction studies, using ibuprofen, verapamil, nitrendipine, captopril, bezafibrate, warfarin, and digoxin. Febuxostat does not influence the plasma protein binding, and the presence of ibuprofen or warfarin does not change the plasma protein binding of febuxostat of ibuprofen or warfarin, overview	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
xanthine + H2O + O2	Homo sapiens	-	urate + H2O2	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
xanthine + H2O + O2	-	Homo sapiens	urate + H2O2	-	?

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Release 2023.1 (January 2023)